Ledipasvir (D-tartrate)

Base Information

Chemical Name:Ledipasvir (D-tartrate)
CAS No.:1502654-87-6
Molecular Formula:C49H54F2N8O6.x(C4H6O6)
Molecular Weight:1039.1
Hs Code.:

Synonyms:GS 5885 D-tartrate;GS5885 D-tartrate);HY-15602B (GS-5885 D-tartrate

Suppliers and Price of Ledipasvir (D-tartrate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
LedipasvirD-tartrate 98+%
10mg
$ 193.00

Crysdot
LedipasvirD-tartrate 98+%
5mg
$ 109.00

Crysdot
LedipasvirD-tartrate 98+%
100mg
$ 1645.00

Crysdot
LedipasvirD-tartrate 98+%
50mg
$ 875.00

ChemScene
LedipasvirD-tartrate 96.89%
100mg
$ 540.00

ChemScene
LedipasvirD-tartrate 96.89%
50mg
$ 300.00

ChemScene
LedipasvirD-tartrate 96.89%
10mg
$ 108.00

ChemScene
LedipasvirD-tartrate 96.89%
5mg
$ 84.00

Total 6 raw suppliers

Chemical Property of Ledipasvir (D-tartrate)

Chemical Property:

PSA：289.70000
LogP:7.14230

Purity/Quality:

97% ^*data from raw suppliers

LedipasvirD-tartrate 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ledipasvir (D-tartrate)

There total 9 articles about Ledipasvir (D-tartrate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 147-71-7,138508-61-9
D-tartaric acid

: 1502655-48-2
(1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)carbamicacid methyl ester acetone salt

: 1502654-87-6
(1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)carbamicacid methyl ester D-tartrate salt

Guidance literature:: In ethanol; ethyl acetate; at 50 ℃; for 16h;

Reference yield: 65.6%

: 147-71-7,138508-61-9
D-tartaric acid

: 1256388-51-8
methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

: 1502654-87-6
(1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)carbamicacid methyl ester D-tartrate salt

Guidance literature:: In ethyl acetate; at 23 - 50 ℃; for 16h;

Reference yield:

: 1499193-65-5
(1R,3S,4S)-tert-butyl 3-(6-(7-(2-((S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptan-6-yl)-1H-imidazol-5-yl)-9,9-difluoro-9H-fluoren-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

: 1502654-87-6
(1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)carbamicacid methyl ester D-tartrate salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water; acetonitrile / 2 h / 65 °C

2.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 0 - 23 °C

2.2: 15 h

3.1: ethyl acetate; ethanol / 16 h / 50 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;