2,5-Piperazinedione,3,6-diethyl-,(3S-cis)-(9CI)

Base Information

• Chemical Name: 2,5-Piperazinedione,3,6-diethyl-,(3S-cis)-(9CI)
• CAS No.: 164453-64-9
• Molecular Formula: C8H14N2O2
• Molecular Weight: 170.211
• Mol file: 164453-64-9.mol

Synonyms:2,5-Piperazinedione,3,6-diethyl-,(3S-cis)-(9CI)

Chemical Property of 2,5-Piperazinedione,3,6-diethyl-,(3S-cis)-(9CI)

Chemical Property:

• Melting Point: 258 - 260 °C
• Boiling Point: 441.0±38.0 °C(Predicted)
• PKA: 12.97±0.60(Predicted)
• PSA: 58.20000
• Density: 1.021±0.06 g/cm3(Predicted)
• LogP: 0.44720

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-Piperazinedione,3,6-diethyl-,(3S-cis)-(9CI)

There total 2 articles about 2,5-Piperazinedione,3,6-diethyl-,(3S-cis)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-aminobutyric acid methyl ester (2483-62-7,15399-11-8,15399-22-1,74645-03-7) → (3S,6S)-3,6-diethylpiperazine-2,5-dione (164453-64-9)

Guidance literature:

With nitrogen; at 100 - 110 ℃; for 20h;

Reference yield:

→ (3S,6S)-3,6-diethylpiperazine-2,5-dione (164453-64-9)

Guidance literature:

2,5-Dibenzyloxy-3,6-diethylpyrazin, H2/Pd/C;

Reference yield: 68.0%

(3S,6S)-3,6-diethylpiperazine-2,5-dione (164453-64-9) → (S)-2-aminobutan-1-ol (5856-62-2)

Guidance literature:

With C₂₄H₂₀ClN₂OPRu; potassium tert-butylate; hydrogen; In tetrahydrofuran; at 110 ℃; for 48h; under 2280.15 - 30402 Torr; Inert atmosphere; Schlenk technique; Autoclave;

DOI:10.1039/d0cc04550k

upstream raw materials:

(S)-2-aminobutyric acid methyl ester

Downstream raw materials:

(S)-2-aminobutan-1-ol

Refernces