1-Piperidinecarboxylic acid, 4-(1H-pyrazol-3-yl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-(1H-pyrazol-3-yl)-, 1,1-dimethylethyl ester
• CAS No.: 278798-07-5
• Molecular Formula: C13H21N3O2
• Molecular Weight: 251.329
• Mol file: 278798-07-5.mol

Synonyms:1-Piperidinecarboxylic acid, 4-(1H-pyrazol-3-yl)-, 1,1-dimethylethyl ester;tert-butyl 4-(1H-pyrazol-3-yl)piperidine-1-carboxylate

Chemical Property of 1-Piperidinecarboxylic acid, 4-(1H-pyrazol-3-yl)-, 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 405.7±38.0 °C(Predicted)
• PKA: 14.12±0.10(Predicted)
• PSA: 58.22000
• Density: 1.140±0.06 g/cm3(Predicted)
• LogP: 2.46210

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-(1H-pyrazol-3-yl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(1H-pyrazol-3-yl)-, 1,1-dimethylethyl ester

There total 9 articles about 1-Piperidinecarboxylic acid, 4-(1H-pyrazol-3-yl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-(1H-pyrazol-3-yl)piperidine dihydrochloride (690262-00-1) → tert-butyl 4-(1H-pyrazol-3-yl)piperidine-1-carboxylate (278798-07-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(1H-pyrazol-3-yl)piperidine-1-carboxylate (278798-07-5)

Guidance literature:

1-benzyl-4-(1H-pyrazol-3-yl)-piperidine; With formic acid; palladium 10% on activated carbon; In ethanol; at 20 ℃;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane;

Reference yield:

tert-butyl 4-[(E)-3-(dimethylamino)prop-2-enoyl]piperidine-1-carboxylate (1799799-87-3) → tert-butyl 4-(1H-pyrazol-3-yl)piperidine-1-carboxylate (278798-07-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 15 - 85 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01531

upstream raw materials:

di-tert-butyl dicarbonate

4-(1H-pyrazol-3-yl)piperidine dihydrochloride

4-acetyl-1-(t-butoxycarbonyl)piperidine

tert-butyl 4-[(E)-3-(dimethylamino)prop-2-enoyl]piperidine-1-carboxylate

Downstream raw materials:

4-(1H-pyrazol-3-yl)piperidine hydrochloride salt