Tcs OX2 29

Base Information

Chemical Name:Tcs OX2 29
CAS No.:372523-75-6
Molecular Formula:C₂₃H₃₁N₃O₃
Molecular Weight:397.517
Hs Code.:
UNII:KH2US47J8R
DSSTox Substance ID:DTXSID801028419
Nikkaji Number:J2.038.488C
Wikipedia:TCS-OX2-29
Wikidata:Q12747053
Pharos Ligand ID:CTC7DKT7BUZL
ChEMBL ID:CHEMBL142009
Mol file:372523-75-6.mol

Synonyms:(2S)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone hydrochloride;1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone;TCS OX2 29;TCSOX229

Suppliers and Price of Tcs OX2 29

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TCS OX2 29
10mg
$ 502.00

TRC
TCSOX229
10mg
$ 205.00

Tocris
TCSOX229 ≥98%(HPLC)
50
$ 952.00

Tocris
TCSOX229 ≥98%(HPLC)
10
$ 227.00

DC Chemicals
TCS-OX2-29 >98%
1 g
$ 1950.00

DC Chemicals
TCS-OX2-29 >98%
100 mg
$ 600.00

CSNpharm
TCS-OX2-29
1mg
$ 61.00

CSNpharm
TCS-OX2-29
5mg
$ 112.00

CSNpharm
TCS-OX2-29
100mg
$ 1084.00

ChemScene
TCS-OX2-29 99.82%
100mg
$ 1188.00

Total 16 raw suppliers

Chemical Property of Tcs OX2 29

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:570.839°C at 760 mmHg
Flash Point:299.033°C
PSA：63.69000
Density:1.128g/cm³
LogP:4.31880
Storage Temp.:Desiccate at +4°C
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:397.23654186
Heavy Atom Count:29
Complexity:530

Purity/Quality:

99%, ^*data from raw suppliers

TCS OX2 29 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C(C(=O)N1CCC2=CC(=C(C=C2C1)OC)OC)NCC3=CC=NC=C3
Isomeric SMILES:CC(C)(C)[C@@H](C(=O)N1CCC2=CC(=C(C=C2C1)OC)OC)NCC3=CC=NC=C3
Uses TCS OX2 29 is a potent and selective orexin-2 receptor (OX2) antagonist.

Technology Process of Tcs OX2 29

There total 4 articles about Tcs OX2 29 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 372523-75-6
TCS-OX2-29

Guidance literature:: Multi-step reaction with 3 steps

1: PyBrop; DMAP; pyridine

2: HCl / ethyl acetate

3: NaBH(OAc)3

With pyridine; hydrogenchloride; dmap; sodium tris(acetoxy)borohydride; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In ethyl acetate;
DOI:10.1016/j.bmcl.2003.08.038

Reference yield:

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 372523-75-6
TCS-OX2-29

Guidance literature:: Multi-step reaction with 3 steps

1: PyBrop; DMAP; pyridine

2: HCl / ethyl acetate

3: NaBH(OAc)3

With pyridine; hydrogenchloride; dmap; sodium tris(acetoxy)borohydride; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In ethyl acetate;
DOI:10.1016/j.bmcl.2003.08.038

Reference yield:

: 372523-99-4
[1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-2,2-dimethyl-propyl]-carbamic acid tert-butyl ester

: 372523-75-6
TCS-OX2-29

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethyl acetate

2: NaBH(OAc)3

With hydrogenchloride; sodium tris(acetoxy)borohydride; In ethyl acetate;
DOI:10.1016/j.bmcl.2003.08.038