3 - (Boc-aMino)-pyrrolidin-3 - carboxylic acid Methyl ester

Base Information

• Chemical Name: 3 - (Boc-aMino)-pyrrolidin-3 - carboxylic acid Methyl ester
• CAS No.: 1382035-21-3
• Molecular Formula: C11H20N2O4
• Molecular Weight: 244.2875
• Hs Code.: 2933998090
• Mol file: 1382035-21-3.mol

Synonyms:3 - (Boc-aMino)-pyrrolidin-3 - carboxylic acid Methyl ester;Methyl 3-((tert-butoxycarbonyl)aMino)pyrrolidine-3-carboxylate;Methyl 3-(Boc-amino)pyrrolidine-3-carboxylate

Chemical Property of 3 - (Boc-aMino)-pyrrolidin-3 - carboxylic acid Methyl ester

Chemical Property:

• PSA: 80.15000
• LogP: 0.94940
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Methyl 3-(Boc-amino)pyrrolidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3 - (Boc-aMino)-pyrrolidin-3 - carboxylic acid Methyl ester

There total 5 articles about 3 - (Boc-aMino)-pyrrolidin-3 - carboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.8%

methyl 1-benzyl-3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylate (675834-17-0) → methyl 3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylate (1382035-21-3) + methyl 3-((tert-butoxycarbonyl)amino)-1-(5-(trifluoromethyl)pyridin-3-yl)pyrrolidine-3-carboxylate

Guidance literature:

Reference yield:

methyl (R)-1-benzyl-3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylate → methyl (R)-3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylate (1382035-21-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 30 ℃; for 20h; under 2585.81 Torr;

Reference yield:

methyl 1-benzyl-3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylate (675834-17-0) → methyl (R)-3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylate (1382035-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ChiralPak AD, 300x50 mm I.D., 10μm / Resolution of racemate

2: palladium on activated charcoal; hydrogen / methanol / 20 h / 30 °C / 2585.81 Torr

With palladium on activated charcoal; hydrogen; In methanol;

upstream raw materials:

methyl 1-benzyl-3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylate

methyl 2-[(tert-butoxycarbonyl)amino]acrylate

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