Bis[1-(2-nitrophenyl)ethyl] N,N-Diisopropylphosphoramidite

Base Information

• Chemical Name: Bis[1-(2-nitrophenyl)ethyl] N,N-Diisopropylphosphoramidite
• CAS No.: 207516-14-1
• Molecular Formula: C22H30N3O6P
• Molecular Weight: 463.47
• DSSTox Substance ID: DTXSID00443276
• Nikkaji Number: J1.296.219C
• Mol file: 207516-14-1.mol

Synonyms:207516-14-1;Bis[1-(2-nitrophenyl)ethyl] N,N-Diisopropylphosphoramidite;N-[bis[1-(2-nitrophenyl)ethoxy]phosphanyl]-N-propan-2-ylpropan-2-amine;Phosphoramidous acid, bis(1-methylethyl)-, bis[1-(2-nitrophenyl)ethyl] ester (9CI);SCHEMBL15643656;DTXSID00443276;NHOJISHKGBWJKJ-UHFFFAOYSA-N;AKOS025294876;FT-0663352;J-013588;N,N-Diisopropylamide phosphorous acid bis(alpha-methyl-2-nitrobenzyl) ester

Chemical Property of Bis[1-(2-nitrophenyl)ethyl] N,N-Diisopropylphosphoramidite

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 48-50°C
• Boiling Point: 508.296°C at 760 mmHg
• PKA: 3.35±0.70(Predicted)
• Flash Point: 261.208°C
• PSA: 126.93000
• LogP: 7.75050
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• XLogP3: 5.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 463.18722268
• Heavy Atom Count: 32
• Complexity: 562

Purity/Quality:

98%Min ^*data from raw suppliers

Bis[1-(2-nitrophenyl)ethyl]N,N-Diisopropylphosphoramidite ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N(C(C)C)P(OC(C)C1=CC=CC=C1[N+](=O)[O-])OC(C)C2=CC=CC=C2[N+](=O)[O-]

Technology Process of Bis[1-(2-nitrophenyl)ethyl] N,N-Diisopropylphosphoramidite

There total 2 articles about Bis[1-(2-nitrophenyl)ethyl] N,N-Diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(2-nitrophenyl)ethan-1-ol (80379-10-8,108530-03-6,142631-59-2,3205-25-2) + N,N-diisopropylphosphoramide dichloride (921-26-6) → bis-[1-(2-nitrophenyl)ethyl]-N,N-diisopropylphosphoramidite (207516-14-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -20 - 20 ℃;

DOI:10.1080/00397910008087172

Reference yield:

2-acetylnitrobenzene (577-59-3) → bis-[1-(2-nitrophenyl)ethyl]-N,N-diisopropylphosphoramidite (207516-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / DIBAL-H / tetrahydrofuran; toluene / 0.25 h / 0 °C

2: 80 percent / Et₃N / tetrahydrofuran / -20 - 20 °C

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; toluene; 1: Reduction / 2: Condensation;

DOI:10.1080/00397910008087172

Reference yield: 52.0%

2,3,4,2',3',4′,6'-heptakis-O-(trimethylsilyl)-α,α-trehalose (60065-05-6) + bis-[1-(2-nitrophenyl)ethyl]-N,N-diisopropylphosphoramidite (207516-14-1) → 6-O-bis[1-(2-nitrophenyl)ethoxyphosphoryl]-D-trehalose (1404341-61-2)

Guidance literature:

2,3,4,2',3',4′,6'-heptakis-O-(trimethylsilyl)-α,α-trehalose; bis-[1-(2-nitrophenyl)ethyl]-N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; acetonitrile; at 0 - 5 ℃; for 18h; Inert atmosphere;

With tert-butyl alcohol; In decane; dichloromethane; acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;

In methanol; for 1h; Inert atmosphere;

upstream raw materials:

1-(2-nitrophenyl)ethan-1-ol

N,N-diisopropylphosphoramide dichloride

2-acetylnitrobenzene

Downstream raw materials:

ortho-nitroso acetophenone

Phosphoric acid (E)-(2S,3R)-2-amino-3-hydroxy-octadec-4-enyl ester bis-[1-(2-nitro-phenyl)-ethyl] ester

(4S,5R)-4-{Bis-[1-(2-nitro-phenyl)-ethoxy]-phosphoryloxymethyl}-2,2-dimethyl-5-((E)-pentadec-1-enyl)-oxazolidine-3-carboxylic acid tert-butyl ester

6-O-bis[1-(2-nitrophenyl)ethoxyphosphoryl]-D-trehalose

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 207516-14-1 BIS[1-(2-NITROPHENYL)ETHYL] N,N-DIISOPROPYLPHOSPHORAMIDITE

Send

Send

Metric Ton KG G Pound L ML

Send

Send