1-Azabicyclo[2.2.2]octane-2-carbonitrile, (2R)-

Base Information

• Chemical Name: 1-Azabicyclo[2.2.2]octane-2-carbonitrile, (2R)-
• CAS No.: 885517-05-5
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Hs Code.: 2933998090
• Mol file: 885517-05-5.mol

Synonyms:1-Azabicyclo[2.2.2]octane-2-carbonitrile, (2R)-;(2R)-1-Azabicyclo[2.2.2]octane-2-carbonitrile

Chemical Property of 1-Azabicyclo[2.2.2]octane-2-carbonitrile, (2R)-

Chemical Property:

• PSA: 27.03000
• LogP: 0.93218

Purity/Quality:

97% ^*data from raw suppliers

(2R)-1-Azabicyclo[2.2.2]octane-2-carbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Azabicyclo[2.2.2]octane-2-carbonitrile, (2R)-

There total 22 articles about 1-Azabicyclo[2.2.2]octane-2-carbonitrile, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

methanesulfonic acid 1-cyano-2-piperidin-4-yl-ethyl ester → quinuclidine-2-carbonitrile (90196-91-1,885517-05-5)

Guidance literature:

With triethylamine; In acetonitrile; Reflux;

DOI:10.1021/acs.jmedchem.9b01427

Reference yield:

1-aza-bicyclo[2.2.2]octane-2-carboxylic acid amide (90152-76-4) → quinuclidine-2-carbonitrile (90196-91-1,885517-05-5)

Guidance literature:

Reference yield:

(+/-)-ethyl quinuclidine-2-carboxylate (112176-92-8,39926-11-9) → quinuclidine-2-carbonitrile (90196-91-1,885517-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ / methanol / 120 °C

2: triphosgene, pyridine / 0 °C

With pyridine; bis(trichloromethyl) carbonate; ammonia; In methanol;

DOI:10.1021/ja00083a014

upstream raw materials:

1-aza-bicyclo[2.2.2]octane-2-carboxylic acid amide

(+/-)-ethyl quinuclidine-2-carboxylate

4-(2-Hydroxyethyl)piperidine

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester