5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]thieno[2,3-b]thiophene-2-sulfonamide

Base Information

Chemical Name:5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]thieno[2,3-b]thiophene-2-sulfonamide
CAS No.:133445-74-6
Molecular Formula:C₁₀H₁₄N₂O₄S₄
Molecular Weight:354.496
Hs Code.:
Mol file:133445-74-6.mol

Synonyms:5-[(2-Methylsulfonylethylamino)methyl]thieno[2,3-b]thiophene-2-sulfonamide;5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]thieno[2,3-b]thiophene-2-sulfonamide

Suppliers and Price of 5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]thieno[2,3-b]thiophene-2-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]thieno[2,3-b]thiophene-2-sulfonamide

Chemical Property:

PSA：179.57000
LogP:3.99720

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]thieno[2,3-b]thiophene-2-sulfonamide

There total 12 articles about 5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]thieno[2,3-b]thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122266-99-3
5-[(2-Methylsulfanyl-ethylamino)-methyl]-thieno[2,3-b]thiophene-2-sulfonic acid amide

: 133445-74-6
5-[(2-Methanesulfonyl-ethylamino)-methyl]-thieno[2,3-b]thiophene-2-sulfonic acid amide

Guidance literature:: With sodium periodate; In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.1021/jm00110a008

Reference yield:

: 31486-85-8
2-Formylthieno<2,3-b>thiophene

: 133445-74-6
5-[(2-Methanesulfonyl-ethylamino)-methyl]-thieno[2,3-b]thiophene-2-sulfonic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: 4.08 g / p-toluenesulfonic acid, methyl orthoformate / toluene / 45 - 50 °C

3: concd. NH₄OH / acetone / 1.5 h

4: 2.10 g / p-toluenesulfonic acid / acetone / 1 h / Ambient temperature

5: NH₃, HCl / methanol / 0.08 h / Heating

6: NaBH₄ / methanol; tetrahydrofuran / 0.5 h

7: aq. sodium periodate / tetrahydrofuran / 24 h / Ambient temperature

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; sodium periodate; ammonia; toluene-4-sulfonic acid; trimethyl orthoformate; In tetrahydrofuran; methanol; acetone; toluene;
DOI:10.1021/jm00110a008

Reference yield:

: 20969-37-3
methyl thieno[2,3-b]thiophene-2-carboxylate

: 133445-74-6
5-[(2-Methanesulfonyl-ethylamino)-methyl]-thieno[2,3-b]thiophene-2-sulfonic acid amide

Guidance literature:: Multi-step reaction with 9 steps

1: LiAlH₄ / diethyl ether / 3 h / Ambient temperature

2: 13.10 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

3: 4.08 g / p-toluenesulfonic acid, methyl orthoformate / toluene / 45 - 50 °C

5: concd. NH₄OH / acetone / 1.5 h

6: 2.10 g / p-toluenesulfonic acid / acetone / 1 h / Ambient temperature

7: NH₃, HCl / methanol / 0.08 h / Heating

8: NaBH₄ / methanol; tetrahydrofuran / 0.5 h

9: aq. sodium periodate / tetrahydrofuran / 24 h / Ambient temperature

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; ammonia; toluene-4-sulfonic acid; pyridinium chlorochromate; trimethyl orthoformate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/jm00110a008