5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

Base Information

Chemical Name:5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide
CAS No.:1272353-82-8
Molecular Formula:C25H20N6O2S
Molecular Weight:468.539
Hs Code.:
Mol file:1272353-82-8.mol

Synonyms:5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide;BMS-919373

Suppliers and Price of 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

A1 Biochem Labs
BMS-919373 95%
20 mg
$ 1500.00

Total 2 raw suppliers

Chemical Property of 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

Chemical Property:

PSA：132.13000
LogP:5.86740

Purity/Quality:

98% ^*data from raw suppliers

BMS-919373 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses BMS-919373 (CAS# 1272353-82-8) is an intermediate in the synthesis of clinical candidate 5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamide as a selective IKur inhibitor for potential treatment of atrial fibrillation.

Technology Process of 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

There total 23 articles about 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1272356-31-6
N-(tert-butyl)-5-(5-phenyl-4-((pyridin-2ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

: 1272353-82-8
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

Guidance literature:: With hydrogenchloride; In water; at 80 ℃; for 3h;
DOI:10.1021/acs.joc.8b02254

Reference yield:

: 1083326-26-4
pyridine-3-sulfonamide-5-ylboronic acid pinacol ester

: 1272353-93-1
2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

: 1272353-82-8
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 62009-33-0
5-bromopyridine-3-sulfonamide

: 1272353-82-8
5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C / Inert atmosphere

With potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;