5α-Androstan-16-one

Base Information

• Chemical Name: 5α-Androstan-16-one
• CAS No.: 1032-16-2
• Molecular Formula: C19H30O
• Molecular Weight: 274.447
• Mol file: 1032-16-2.mol

Synonyms:5α-Androstan-16-one

Chemical Property of 5α-Androstan-16-one

Chemical Property:

• Melting Point: 106 - 107 °C
• PSA: 17.07000
• LogP: 4.98830

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5α-Androstan-16-one

There total 4 articles about 5α-Androstan-16-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

17β-trimethylsiloxy-5α-androstan-16-one (228259-83-4) → 15α-androstane-16-one (1032-16-2) + 5alpha-androstan-17-one (963-74-6) + 17β-hydroxy-5α-androstan-16-one (35494-02-1) + 16β-(17-oxo-5α-androstan-16α-yloxy)-5α-androstan-17-one + 16β-(16-oxo-5α-androstan-17β-yloxy)-5α-androstan-17-one

Guidance literature:

With trimethylsilyl iodide; In chloroform; for 1h; Product distribution; Mechanism; Ambient temperature; other steroidal 16,17-ketols, their silyl ethers and 16- and 17-iodoketone analogs; var. time;

DOI:10.1248/cpb.47.548

Reference yield:

17β-hydroxy-5α-androstan-16-one (35494-02-1) → 15α-androstane-16-one (1032-16-2) + 5alpha-androstan-17-one (963-74-6)

Guidance literature:

With trimethylsilyl iodide; In chloroform; for 1h; Yield given; Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1248/cpb.46.1857

Reference yield:

16β-hydroxy-5α-androstan-17-one (112925-02-7) → 15α-androstane-16-one (1032-16-2) + 5alpha-androstan-17-one (963-74-6)

Guidance literature:

With trimethylsilyl iodide; In chloroform; for 1h; Yield given; Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1248/cpb.46.1857

upstream raw materials:

17β-hydroxy-5α-androstan-16-one

16α-hydroxy-5α-androstan-17-one

16β-hydroxy-5α-androstan-17-one

17β-trimethylsiloxy-5α-androstan-16-one

Downstream raw materials:

5α-Androstan-16β-ol

5α-Androstan-6,11-dion

5α-Androstan-1,6-dion

N-benzyl-16-aza-5α-androstane