tert-butyl 7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate

Base Information

Chemical Name:tert-butyl 7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate
CAS No.:886449-70-3
Molecular Formula:C₁₉H₂₆N₂O₃
Molecular Weight:330.427
Hs Code.:

Synonyms:1,7-Diazaspiro[4.4]nonane-1-carboxylic acid, 6-oxo-7-(phenylMethyl)-, 1,1-diMethylethyl ester

Suppliers and Price of tert-butyl 7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of tert-butyl 7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate

Chemical Property:

Vapor Pressure:4.99E-10mmHg at 25°C
Boiling Point:497.3°C at 760 mmHg
Flash Point:254.6°C
Density:1.18g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate

There total 7 articles about tert-butyl 7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 2-(2-benzylamino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 886449-70-3
(+/-)-7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester

Guidance literature:: In toluene; for 16h; Heating;
DOI:10.1016/j.tetlet.2006.03.021

Reference yield:

: 850426-34-5
1-tert-butyl 2-methyl 2-(2-oxoethyl)pyrrolidine-1,2-dicarboxylate

: 886449-70-3
(+/-)-7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 20 °C

1.2: sodium borohydride / ethanol / 20 °C

2.1: triethylamine / dimethylformamide / 70 °C

With triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.06.050

Reference yield:

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 886449-70-3
(+/-)-7-benzyl-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 74 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

2.1: LiHMDS / tetrahydrofuran / -78 °C

2.2: 80 percent / tetrahydrofuran / 20 °C

3.1: 74 percent / OsO₄; NaIO₄; H₂O / tetrahydrofuran / 20 °C

4.1: ethanol / 20 °C

4.2: sodium borohydride / ethanol / 20 °C

5.1: triethylamine / dimethylformamide / 70 °C

With dmap; sodium periodate; osmium(VIII) oxide; water; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.06.050