8-Chloro-3,4-dihydro-4-methyl-2H-pyridazino[4,5-b][1,4]oxazine

Base Information

• Chemical Name: 8-Chloro-3,4-dihydro-4-methyl-2H-pyridazino[4,5-b][1,4]oxazine
• CAS No.: 66643-52-5
• Molecular Formula: C₇H₈ClN₃O
• Molecular Weight: 185.613
• Mol file: 66643-52-5.mol

Synonyms:8-Chloro-3,4-dihydro-4-methyl-2H-pyridazino[4,5-b][1,4]oxazine

Chemical Property of 8-Chloro-3,4-dihydro-4-methyl-2H-pyridazino[4,5-b][1,4]oxazine

Chemical Property:

• PSA: 38.25000
• LogP: 1.02360

Purity/Quality:

97% ^*data from raw suppliers

8-Chloro-3,4-dihydro-4-methyl-2H-pyridazino[4,5-b][1,4]oxazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Chloro-3,4-dihydro-4-methyl-2H-pyridazino[4,5-b][1,4]oxazine

There total 1 articles about 8-Chloro-3,4-dihydro-4-methyl-2H-pyridazino[4,5-b][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,4-dichloro-5-<(2-hydroxyethyl)methylamino>-pyridazine (66643-51-4) → 8-chloro-3,4-dihydro-4-methyl-2H-pyridazino<4,5-b>-1,4-oxazine (66643-52-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 2h; Reflux;

Reference yield:

8-chloro-3,4-dihydro-4-methyl-2H-pyridazino<4,5-b>-1,4-oxazine (66643-52-5) → (4-fluoro-benzyl)-[3-(4-methoxy-phenyl)-6-methyl-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine (1313732-94-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NCS / acetonitrile / 3 h / 50 °C

2: toluene-4-sulfonic acid; triethylamine / 1,4-dioxane / 100 °C

3: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 20 - 110 °C

With toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; acetonitrile;

Reference yield:

8-chloro-3,4-dihydro-4-methyl-2H-pyridazino<4,5-b>-1,4-oxazine (66643-52-5) → [2-(4-fluoro-phenyl)-ethyl]-[3-(4-methoxy-phenyl)-9-methyl-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine (1313732-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NCS / acetonitrile / 3 h / 50 °C

2: toluene-4-sulfonic acid; triethylamine / 1,4-dioxane / 100 °C

3: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 20 - 110 °C

With toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; acetonitrile;

upstream raw materials:

3,4-dichloro-5-<(2-hydroxyethyl)methylamino>-pyridazine

Downstream raw materials:

[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(tetrahydro-pyran-4-yl)-amine

(3,4-dimethoxy-benzyl)-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine

(3,4-dimethoxy-benzyl)-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine

[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-(2-pyridin-3-yl-ethyl)-amine