2-Naphthalenecarboxylicacid,2-amino-1,2,3,4-tetrahydro-8-hydroxy-,(S)-(9CI)

Base Information

• Chemical Name: 2-Naphthalenecarboxylicacid,2-amino-1,2,3,4-tetrahydro-8-hydroxy-,(S)-(9CI)
• CAS No.: 168629-05-8
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.23
• Mol file: 168629-05-8.mol

Synonyms:2-Naphthalenecarboxylicacid,2-amino-1,2,3,4-tetrahydro-8-hydroxy-,(S)-(9CI)

Chemical Property of 2-Naphthalenecarboxylicacid,2-amino-1,2,3,4-tetrahydro-8-hydroxy-,(S)-(9CI)

Chemical Property:

• Melting Point: None °C
• PSA: 83.55000
• LogP: 1.36330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Naphthalenecarboxylicacid,2-amino-1,2,3,4-tetrahydro-8-hydroxy-,(S)-(9CI)

There total 1 articles about 2-Naphthalenecarboxylicacid,2-amino-1,2,3,4-tetrahydro-8-hydroxy-,(S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S)-2-benzamido-1,2,3,4-tetrahydro-8-hydroxynaphthalene-2-carboxylic acid (168629-02-5) → (S)-2-amino-1,2,3,4-tetrahydro-8-hydroxynaphthalene-2-carboxylic acid (168629-05-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1002/hlca.19950780613

Reference yield:

N-(benzyloxycarbonyl)succinimide (75315-63-8) + (S)-2-amino-1,2,3,4-tetrahydro-8-hydroxynaphthalene-2-carboxylic acid (168629-05-8) → (S)-2-benzyloxycarbonyl-amino-8-hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

Guidance literature:

With sodium bicarbonate; sodium chloride; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-amino-1,2,3,4-tetrahydro-8-hydroxynaphthalene-2-carboxylic acid (168629-05-8) → (S)-2-<(tert-butoxy)carbonylamino>-8-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (168629-12-7)

Guidance literature:

With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 50 deg C, 1 h; 2.) CH₂Cl₂, 50 deg C, 1 h; 3.) 50 deg C, 17 h;

DOI:10.1002/hlca.19950780613

upstream raw materials:

(S)-2-benzamido-1,2,3,4-tetrahydro-8-hydroxynaphthalene-2-carboxylic acid

Downstream raw materials:

(S)-2-<(tert-butoxy)carbonylamino>-8-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid