Chemical Property of n5-Iminoethyl-l-ornithine
Chemical Property:
- Appearance/Colour:white powder.
- Vapor Pressure:4E-06mmHg at 25°C
- Melting Point:225-226oC
- Boiling Point:358.9 °C at 760 mmHg
- Flash Point:170.9 °C
- PSA：99.20000
- Density:1.26 g/cm3
- LogP:0.95620
- Storage Temp.:-20°C
- Solubility.:Methanol (Slightly), Water (Slightly)
- XLogP3:-3.6
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:5
- Exact Mass:173.116426730
- Heavy Atom Count:12
- Complexity:180
- Purity/Quality:
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98%Min *data from raw suppliers
L-NIO dihydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC(=NCCCC(C(=O)O)N)N
- Isomeric SMILES:CC(=NCCC[C@@H](C(=O)O)N)N
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Description
L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.
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Uses
A potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
