17β-Acetyloxyestr-5(10)-en-3-one ethylene acetal

Base Information

• Chemical Name: 17β-Acetyloxyestr-5(10)-en-3-one ethylene acetal
• CAS No.: 18367-54-9
• Molecular Formula: C22H32O4
• Molecular Weight: 360.48708
• Mol file: 18367-54-9.mol

Synonyms:17β-Acetyloxyestr-5(10)-en-3-one ethylene acetal

Chemical Property of 17β-Acetyloxyestr-5(10)-en-3-one ethylene acetal

Chemical Property:

• PSA: 44.76000
• LogP: 4.37800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17β-Acetyloxyestr-5(10)-en-3-one ethylene acetal

There total 3 articles about 17β-Acetyloxyestr-5(10)-en-3-one ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17β-hydroxy-estr-5(10)-en-3-one (1089-78-7) → 3,3-(ethylenedioxy)-5(10)-estren-17β-yl acetate (18367-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsOH / benzene / 19 h / Heating

2: pyridine / 4 h / Ambient temperature

With pyridine; toluene-4-sulfonic acid; In benzene;

DOI:10.1021/jm00383a014

Reference yield:

2-ethyl-2-methyl-1,3-dioxolane (126-39-6) + 19-nortestosterone acetate (1425-10-1) → 3,3-(ethylenedioxy)-5(10)-estren-17β-yl acetate (18367-54-9) + 3,3-(ethylenedioxy)-5-estren-17β-yl acetate

Guidance literature:

With toluene-4-sulfonic acid; at 83 ℃; for 7.5h;

DOI:10.1021/jm990064o

Reference yield:

17β-hydroxyestr-5(10)-en-3-one ethylene acetal (15342-09-3) + acetic anhydride (108-24-7) → 3,3-(ethylenedioxy)-5(10)-estren-17β-yl acetate (18367-54-9)

Guidance literature:

With pyridine; for 4h; Yield given; Ambient temperature;

DOI:10.1021/jm00383a014

upstream raw materials:

17β-hydroxyestr-5(10)-en-3-one ethylene acetal

acetic anhydride

2-ethyl-2-methyl-1,3-dioxolane

19-nortestosterone acetate

Downstream raw materials:

17β-hydroxy-10β-mercaptoestr-4-en-3-one

Refernces

• 1、 Bednarski, Patrick J.,Porubek, David J.,Nelson, Sidney D.. "Thiol-Containing Androgens as Suicide Substrates of Aromatase". . p. 775 - 779. Retrieved 2007/10/02.