4-(4-nitrobenzylamino)piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(4-nitrobenzylamino)piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 888944-25-0
• Molecular Formula: C17H25N3O4
• Molecular Weight: 335.403
• Mol file: 888944-25-0.mol

Synonyms:4-(4-nitrobenzylamino)piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(4-nitrobenzylamino)piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Vapor Pressure: 4.96E-09mmHg at 25°C
• Boiling Point: 470.7°C at 760 mmHg
• Flash Point: 238.5°C
• PSA: 87.39000
• Density: 1.19g/cm³
• LogP: 3.93590

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(4-nitrobenzylamino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-nitrobenzylamino)piperidine-1-carboxylic acid tert-butyl ester

There total 6 articles about 4-(4-nitrobenzylamino)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-amino-1-(t-butoxycarbonyl)piperidine monohydrochloride (189819-75-8) + 4-nitrobenzaldehdye (555-16-8) → 4-(4-nitro-benzylamino)-piperidine-1-carboxylic acid tert-butyl ester (888944-25-0)

Guidance literature:

4-amino-1-(t-butoxycarbonyl)piperidine monohydrochloride; 4-nitrobenzaldehdye; With triethylamine; In methanol; for 21h; Heating / reflux;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 6h;

With sodium hydrogencarbonate; In methanol; water;

Reference yield:

C17H23N3O4 → 4-(4-nitro-benzylamino)-piperidine-1-carboxylic acid tert-butyl ester (888944-25-0)

Guidance literature:

C₁₇H₂₃N₃O₄; With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 0.5h;

With water; sodium hydrogencarbonate; In methanol; ethyl acetate;

Reference yield:

4-nitrobenzaldehdye (555-16-8) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → 4-(4-nitro-benzylamino)-piperidine-1-carboxylic acid tert-butyl ester (888944-25-0)

Guidance literature:

4-nitrobenzaldehdye; 1-(tert-butoxycarbonyl)-4-aminopiperidine; With titanium(IV) isopropylate; In ethanol; at 0 - 20 ℃;

With sodium tetrahydroborate; acetic acid; In ethanol; at 20 ℃; for 3h;

upstream raw materials:

4-amino-1-(t-butoxycarbonyl)piperidine monohydrochloride

4-nitrobenzaldehdye

1-(tert-butoxycarbonyl)-4-aminopiperidine

1-bromomethyl-4-nitro-benzene

Downstream raw materials:

4-[(4-Nitro-benzyl)-(4-pentyl-benzoyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

6-methoxy-4-(2-(4-(4-nitrobenzylamino)piperidin-1-yl)ethyl)quinoline-3-carbonitrile

4-[(4-amino-benzyl)-tert-butoxycarbonyl-amino]-piperidine-1-carboxylic acid tert-butyl ester

C₁₇H₂₇N₃O₂