1-(4-Methoxyphenyl)ethylaMine Hydrochloride

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)ethylaMine Hydrochloride
• CAS No.: 90642-63-0
• Molecular Formula: C9H14ClNO
• Molecular Weight: 187.669
• Hs Code.: 2922290090
• Mol file: 90642-63-0.mol

Synonyms:1-(4-Methoxyphenyl)ethylaMine Hydrochloride

Chemical Property of 1-(4-Methoxyphenyl)ethylaMine Hydrochloride

Chemical Property:

• Vapor Pressure: 0.0034mmHg at 25°C
• Melting Point: 146 °C
• Boiling Point: 277.8°C at 760 mmHg
• Flash Point: 121.8°C
• PSA: 35.25000
• LogP: 3.21720

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Methoxyphenyl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Methoxyphenyl)ethylaMine Hydrochloride

There total 7 articles about 1-(4-Methoxyphenyl)ethylaMine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

p-ethylanisole (1515-95-3) → 1-(4-methoxyphenyl)ethan-1-amine hydrochloride (90642-63-0,574744-39-1,911373-69-8)

Guidance literature:

p-ethylanisole; With Benzophenone imine; copper(l) iodide; 1,10-Phenanthroline; di-tert-butyl peroxide; In chlorobenzene; at 90 ℃; for 48h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In methanol; water; chlorobenzene; at 40 ℃; for 15h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b03505

Reference yield:

4-methoxyacetophenone oxime (2475-92-5) → 1-(4-methoxyphenyl)ethan-1-amine hydrochloride (90642-63-0,574744-39-1,911373-69-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; under 760.051 Torr;

Reference yield:

C9H11NO*ClH (1164111-39-0) → 1-(4-methoxyphenyl)ethan-1-amine hydrochloride (90642-63-0,574744-39-1,911373-69-8)

Guidance literature:

With 2,6-bis(3,5-bis(3,7-bis(trifluoromethyl)naphthalen-1-yl)phenyl)-4H-dinaphtho[2,1-d:1',2'-f][1,3,2]dithiazepine 3,3,5,5-tetraoxide; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate; In tert-butyl methyl ether; methyl cyclohexane; at 20 ℃; for 24h; Inert atmosphere; Molecular sieve;

DOI:10.1055/s-0040-1706413

upstream raw materials:

1-(4-methoxyphenyl)ethanamine

1-(1-azidoethyl)-4-methoxybenzene

p-ethylanisole

4-methoxyacetophenone oxime

Downstream raw materials:

5-Bromo-N-[1-(4-methoxyphenyl)ethyl]thieno[2,3-d]pyrimidin-4-amine

Refernces

• 1、 Kramer, S?ren. "Synthesis of α-Substituted Primary Benzylamines through Copper-Catalyzed Cross-Dehydrogenative Coupling". supporting information. p. 65 - 69. Retrieved 2019/01/04.
• 2、 Murugesan, Kathiravan,Beller, Matthias,Jagadeesh, Rajenahally V.. "Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines". supporting information. p. 5064 - 5068. Retrieved 2019/03/19.