2,2-DIFLUOROCYCLOHEXANAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 2,2-DIFLUOROCYCLOHEXANAMINE HYDROCHLORIDE
• CAS No.: 921602-83-7
• Molecular Formula: C6H11F2N.ClH
• Molecular Weight: 171.618
• Mol file: 921602-83-7.mol

Synonyms:2,2-DIFLUOROCYCLOHEXANAMINE HYDROCHLORIDE;2,2-Difluorocyclohexan-1-aMine hydrochloride

Chemical Property of 2,2-DIFLUOROCYCLOHEXANAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 26.02000
• LogP: 3.02530
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2,2-Difluorocyclohexanaminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIFLUOROCYCLOHEXANAMINE HYDROCHLORIDE

There total 11 articles about 2,2-DIFLUOROCYCLOHEXANAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-(2,2-difluorocyclohexyl)-2,2,2-trifluoroacetamide → 2,2-difluorocyclohexylamine hydrochloride (921602-83-7)

Guidance literature:

With hydrogenchloride; In methanol; water; at 35 ℃;

DOI:10.1016/j.jfluchem.2017.04.012

Reference yield: 7.0%

2,2-difluorocyclohexanecarboxylic acid → 2,2-difluorocyclohexylamine hydrochloride (921602-83-7)

Guidance literature:

2,2-difluorocyclohexanecarboxylic acid; With sodium azide; sulfuric acid; In chloroform; at 20 - 50 ℃; for 54h;

With hydrogenchloride; In diethyl ether; dichloromethane; chloroform;

DOI:10.1016/j.jfluchem.2017.04.012

Reference yield:

2,2,2-trifluoro-N-(trans-2-hydroxycyclohexyl)acetamide → 2,2-difluorocyclohexylamine hydrochloride (921602-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 24 h / -70 - 20 °C / Inert atmosphere

3: hydrogenchloride / water; methanol / 35 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; pyridinium chlorochromate; In methanol; dichloromethane; water;

DOI:10.1016/j.jfluchem.2017.04.012

upstream raw materials:

2,2-dimethoxycyclohexanecarboxylic acid ethyl ester

ethyl 2-oxocyclohexane carboxylate

(2,2-dimethoxycyclohexyl)methanol

(2-oxocyclohexyl)methyl acetate

Downstream raw materials:

C₂₇H₂₄ClF₆N₃O

N-(2,2-difluorocyclohexyl)-2-fluoro-pyridine-4-carboxamide

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