(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide

Base Information

Chemical Name:(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide
CAS No.:697287-41-5
Molecular Formula:C23H25FN2O2
Molecular Weight:380.4552032
Hs Code.:
Mol file:697287-41-5.mol

Synonyms:(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide;N-[(1S)-1-[4-(CyclopropylMethyl)-3,4-dihydro-2H-1,4-benzoxazin-6-yl]ethyl]-3-(2-fluorophenyl)-2-propenaMide

Suppliers and Price of (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide
5mg
$ 645.00

Biosynth Carbosynth
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide
2 mg
$ 462.50

Biosynth Carbosynth
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide
1 mg
$ 254.40

Biosynth Carbosynth
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide
10 mg
$ 1528.80

Biosynth Carbosynth
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide
5 mg
$ 840.90

American Custom Chemicals Corporation
(S)-N-(1-(4-CYCLOPROPYLMETHYL-3,4-DIHYDRO-2H-BENZO(1,4)OXAZIN-6-YL)-ETHYL)-3-(2-FLUORO-PHENYL)ACRYLAMIDE 95.00%
10MG
$ 1871.10

American Custom Chemicals Corporation
(S)-N-(1-(4-CYCLOPROPYLMETHYL-3,4-DIHYDRO-2H-BENZO(1,4)OXAZIN-6-YL)-ETHYL)-3-(2-FLUORO-PHENYL)ACRYLAMIDE 95.00%
1MG
$ 739.20

Total 3 raw suppliers

Chemical Property of (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:180-182°C
Boiling Point:603.44°C at 760 mmHg
PKA:14.27±0.46(Predicted)
Flash Point:318.749°C
PSA：41.57000
Density:1.224g/cm³
LogP:4.78100

Purity/Quality:

97% ^*data from raw suppliers

(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses A potent and efficacious KCNQ2 opener which inibits induced hyperexcitability of rat hippocampal neurons (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide is a potent and efficacious KCNQ2 opener and found to reduce neuronal hyperexcitability in rat hippocampal slices (1).

Technology Process of (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide

There total 13 articles about (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%