2-Amino-4-trifluoromethyl-thiophene-3-carboxylic acid methyl ester

Base Information

Chemical Name:2-Amino-4-trifluoromethyl-thiophene-3-carboxylic acid methyl ester
CAS No.:1094619-74-5
Molecular Formula:C7H6F3NO2S
Molecular Weight:225.19
Hs Code.:
Mol file:1094619-74-5.mol

Synonyms:2-Amino-4-trifluoromethyl-thiophene-3-carboxylic acid methyl ester

Suppliers and Price of 2-Amino-4-trifluoromethyl-thiophene-3-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl2-Amino-4-trifluoromethylthiophene-3-carboxylate
5g
$ 1320.00

Medical Isotopes, Inc.
Methyl2-Amino-4-trifluoromethylthiophene-3-carboxylate
500 mg
$ 650.00

J&W Pharmlab
2-Amino-4-trifluoromethyl-thiophene-3-carboxylicacidmethylester 97%
50mg
$ 156.00

Arctom
Methyl2-amino-4-(trifluoromethyl)thiophene-3-carboxylate 97%
1g
$ 655.00

Total 10 raw suppliers

Chemical Property of 2-Amino-4-trifluoromethyl-thiophene-3-carboxylic acid methyl ester

Chemical Property:

PSA：80.56000
LogP:2.71690

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Amino-4-trifluoromethylthiophene-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate is used as a reagent in the synthesis of highly potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitors which effectively treat type 2 diabetes.

Technology Process of 2-Amino-4-trifluoromethyl-thiophene-3-carboxylic acid methyl ester

There total 1 articles about 2-Amino-4-trifluoromethyl-thiophene-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1094619-73-4
2-amino-4-hydroxy-4-(trifluoromethyl)-4,5-dihydrothiophene-3-carboxylic acid methyl ester

: 1094619-74-5
2-amino-4-(trifluoromethyl)thiophene-3-carboxylic acid methyl ester

Guidance literature:: at 175 ℃; for 0.166667h;

Reference yield:

: 1094619-74-5
2-amino-4-(trifluoromethyl)thiophene-3-carboxylic acid methyl ester

: 64-04-0
phenethylamine

: 1094620-00-4
2-amino-N-phenethyl-4-(trifluoromethyl)thiophene-3-carboxamide

Guidance literature:: phenethylamine; With trimethylaluminum; In toluene; at 5 - 20 ℃; for 2h;

2-amino-4-(trifluoromethyl)thiophene-3-carboxylic acid methyl ester; In toluene; for 1h; Heating / reflux;

With potassium sodium tartrate; water; In toluene;

Reference yield:

: 1094619-74-5
2-amino-4-(trifluoromethyl)thiophene-3-carboxylic acid methyl ester

: 1094620-01-5
2-(2-methoxyphenyl)-5-trifluoromethyl-3-phenethyl-3H-thieno[2,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / toluene / 2 h / 5 - 20 °C

1.2: 1 h / Heating / reflux

2.1: toluene-4-sulfonic acid / toluene / 12 h / 120 °C

With trimethylaluminum; toluene-4-sulfonic acid; In toluene;