Galβ1-3GalNAcα-Bn

Base Information

• Chemical Name: Galβ1-3GalNAcα-Bn
• CAS No.: 141020-28-2
• Molecular Formula: C21H31NO10
• Molecular Weight: 457.47154
• Mol file: 141020-28-2.mol

Synonyms:Benzyl 2-AcetaMido-2,6-dideoxy-3-O-β-D-galactopyranosyl α-D-Galactopyranoside;Galβ1-3GalNAcα-Bn;PhenylMethyl 2-(AcetylaMino)-2,6-dideoxy-3-O-β-D-galactopyranosyl- α-D-galactopyranoside

Chemical Property of Galβ1-3GalNAcα-Bn

Chemical Property:

• PSA: 170.66000
• LogP: -1.16100

Purity/Quality:

98% ^*data from raw suppliers

Benzyl2-Acetamido-2,6-dideoxy-3-O-β-D-galactopyranosylα-D-Galactopyranoside ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Galβ1-3GalNAcα-Bn is useful in the biosynthesis of O-glycoproteins.

Technology Process of Galβ1-3GalNAcα-Bn

There total 5 articles about Galβ1-3GalNAcα-Bn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Benzyl-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-2-acetamido-4-O-acetyl-2,6-didesoxy-α-D-galactopyranosid (141020-27-1) → Benzyl-O-(β-D-galactopyranosyl)-(1->3)-2-acetamido-2,6-didesoxy-α-D-galactopyranosid (141020-28-2)

Guidance literature:

With sodium methylate; In methanol; for 12h; Ambient temperature;

Reference yield:

benzyl 2-acetamido-2,6-dideoxy-α-D-galactopyranoside (81997-63-9) → Benzyl-O-(β-D-galactopyranosyl)-(1->3)-2-acetamido-2,6-didesoxy-α-D-galactopyranosid (141020-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: p-toluenesulfonic acid / CH₂Cl₂ / 2 h / Ambient temperature

2: 80 percent aq. acetic acid / 1 h

3: 1.) molecular sieves 4 Angstroem, 2.) trimethylsilyl triflate / 1.) dichloromethane, 1 h, 2.) r.t., 1 h

4: 95 percent / 0.1 N methanolic NaOMe / methanol / 12 h / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; sodium methylate; toluene-4-sulfonic acid; acetic acid; In methanol; dichloromethane;

Reference yield:

Benzyl-2-acetamido-4-O-acetyl-2,6-didesoxy-α-D-galactopyranosid (141020-26-0) → Benzyl-O-(β-D-galactopyranosyl)-(1->3)-2-acetamido-2,6-didesoxy-α-D-galactopyranosid (141020-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) molecular sieves 4 Angstroem, 2.) trimethylsilyl triflate / 1.) dichloromethane, 1 h, 2.) r.t., 1 h

2: 95 percent / 0.1 N methanolic NaOMe / methanol / 12 h / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; sodium methylate; In methanol;

upstream raw materials:

Benzyl-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-2-acetamido-4-O-acetyl-2,6-didesoxy-α-D-galactopyranosid

2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate

benzyl 2-acetamido-2,6-dideoxy-α-D-galactopyranoside

Benzyl-2-acetamido-4-O-acetyl-2,6-didesoxy-α-D-galactopyranosid

Refernces