4β-Chlorocyclohexanone

Base Information

• Chemical Name: 4β-Chlorocyclohexanone
• CAS No.: 21299-26-3
• Molecular Formula: C6H9ClO
• Molecular Weight: 132.59
• Mol file: 21299-26-3.mol

Synonyms:4-Chlorocyclohexanone;4β-Chlorocyclohexanone

Chemical Property of 4β-Chlorocyclohexanone

Chemical Property:

• Refractive Index: 1.4867 (estimate)
• Boiling Point: 173.38°C (rough estimate)
• PSA: 17.07000
• Density: 1.0461 (rough estimate)
• LogP: 1.73690

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4β-Chlorocyclohexanone

There total 6 articles about 4β-Chlorocyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.1%

4-chlorocyclohexanol (30485-71-3) → 4-chlorocyclohexanone (21299-26-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 2h;

DOI:10.1021/ja00303a023

Reference yield: 10.0%

2-<(trimethylsilyl)oxy>-1,5-hexadiene (57711-32-7) → 4-chlorocyclohexanone (21299-26-3) + dodeca-1,11-diene-5,8-dione (43227-47-0) + 1-chlorohex-5-en-2-one (73193-08-5)

Guidance literature:

With iron(III) chloride; In acetonitrile; for 0.0166667h; Heating;

DOI:10.1021/jo01298a062

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → 4-chlorocyclohexanone (21299-26-3)

Guidance literature:

With hydrogen; In water; at 80 ℃;

DOI:10.1002/asia.201800112

upstream raw materials:

4-chlorocyclohexanol

bicyclo[3.1.0]hexan-2-one

2-<(trimethylsilyl)oxy>-1,5-hexadiene

7-oxabicyclo(2.2.1)heptane

Downstream raw materials:

4-chloro-1-cyclopropyl-1-cyclohexanol

1-(p-Tolyl)-1-hydroxy-4-chlor-cyclohexan

4-chloro-1-hydroxy-cyclohexanecarboxylic acid amide

1-(m-Trifluormethyl-phenyl)-4-chlor-cyclohexen

Refernces

• 1、 Ito, Yoshihiko,Nakatsuka, Masashi,Saegusa, Takeo. "Syntheses of α-Chloro Ketones by Reaction of Silyl Enol Ethers with CuCl2 and FeCl3". . p. 2022 - 2024. Retrieved 2007/10/02.