1α,2α-Dichlorocycloheptane

Base Information

• Chemical Name: 1α,2α-Dichlorocycloheptane
• CAS No.: 32718-96-0
• Molecular Formula: C7H12Cl2
• Molecular Weight: 167.08
• Mol file: 32718-96-0.mol

Synonyms:1α,2α-Dichlorocycloheptane

Chemical Property of 1α,2α-Dichlorocycloheptane

Chemical Property:

• PSA: 0.00000
• LogP: 3.16530

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1α,2α-Dichlorocycloheptane

There total 6 articles about 1α,2α-Dichlorocycloheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Cycloheptene (628-92-2,45509-99-7) → trans-1,2-Dichlorocycloheptane (32616-83-4,32718-96-0,82936-34-3)

Guidance literature:

With dihydrogen peroxide; Vilsmeier's reagent; In methanol; dichloromethane; over 20 deg C;

DOI:10.1016/S0040-4039(00)87212-3

Reference yield: 80.0%

8-oxabicyclo[5.1.0]octane (286-45-3) → cis-1,2-Dichlorocycloheptane (32718-96-0)

Guidance literature:

With tetrachloromethane; triphenylphosphine; for 72h; Heating;

DOI:10.1021/jo00167a048

Reference yield: 77.0%

Cycloheptene (628-92-2,45509-99-7) → cis-1,2-Dichlorocycloheptane (32718-96-0)

Guidance literature:

With 2,6-lutidine N-oxide; chloro-trimethyl-silane; diphenyl diselenide; N-benzyl-N,N,N-triethylammonium chloride; 1-fluoro-pyridinium tetrafluoroborate; In acetonitrile; at 20 ℃; for 4h; stereospecific reaction; Sealed tube; Inert atmosphere;

DOI:10.1038/nchem.2141

upstream raw materials:

Cycloheptene

8-oxabicyclo[5.1.0]octane

Refernces

• 1、 Strehl, Julia,Fastie, Cornelius,Hilt, Gerhard. "The Electrochemical cis-Chlorination of Alkenes". supporting information. p. 17341 - 17345. Retrieved 2021/10/23.
• 2、 Croft, Alan P.,Bartsch, Richard A.. "Comparison of β-Chloro-Activated, Syn and Anti Dehydrochlorinations Induced by Complex Base". . p. 1930 - 1932. Retrieved 2007/10/02.