Desmethyl SCH 442416

Base Information

Chemical Name:Desmethyl SCH 442416
CAS No.:188112-92-7
Molecular Formula:C19H17N7O2
Molecular Weight:375.39
Hs Code.:

Synonyms:Desmethyl SCH 442416

Suppliers and Price of Desmethyl SCH 442416

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Axon Medchem
DesmethylSCH442416 95%
25 mg
$ 682.00

Total 5 raw suppliers

Chemical Property of Desmethyl SCH 442416

Chemical Property:

Melting Point:189-191 °C
PKA:10.07±0.15(Predicted)
PSA：120.29000
Density:1.586g/cm³
LogP:3.23580

Purity/Quality:

97% ^*data from raw suppliers

DesmethylSCH442416 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Desmethyl SCH 442416

There total 8 articles about Desmethyl SCH 442416 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 7-(3-(4-methoxyphenyl)propyl)-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine-5-amine

: 188112-92-7
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenol

Guidance literature:: 7-(3-(4-methoxyphenyl)propyl)-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine-5-amine; With boron tribromide; In dichloromethane; at 20 ℃; for 4h;

With methanol; In dichloromethane; at 0 ℃;
DOI:10.1039/c7md00247e

Reference yield:

: 207233-56-5
7-[3-(4-Benzyloxy-phenyl)-propyl]-2-furan-2-yl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

: 188112-92-7
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenol

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; for 4h; under 2585.7 Torr; Ambient temperature;
DOI:10.1021/jm9708689

Reference yield:

: 3326-71-4
2-furoic acid hydrazide

: 188112-92-7
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 2-methoxyethanol, reflux, 2.) diphenyl ether, 260 deg C, 1.5 h

2: 83 percent / 10percent aq. HCl / 3 h / Heating

3: 1-methyl-2-pyrrolidone, pTsOH / 160 °C

4: H₂ / 10percent Pd/C / methanol; dioxane / 4 h / 2585.7 Torr / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1021/jm9708689