CyclopropaneMethanaMine, 2-[2-(2-Methylpropoxy)phenyl]-, hydrochloride (1:1), (1R,2R)-rel-

Base Information

• Chemical Name: CyclopropaneMethanaMine, 2-[2-(2-Methylpropoxy)phenyl]-, hydrochloride (1:1), (1R,2R)-rel-
• CAS No.: 1344119-14-7
• Molecular Formula: C₁₄H₂₁NO*ClH
• Molecular Weight: 255.788
• Hs Code.: 2922290090
• Mol file: 1344119-14-7.mol

Synonyms:CyclopropaneMethanaMine, 2-[2-(2-Methylpropoxy)phenyl]-, hydrochloride (1:1), (1R,2R)-rel-;1-{(1R,2R)-2-[2-(2-Methylpropoxy)phenyl]cyclopropyl}methanamine hydrochloride;((1R,2R)-rel-2-(2-Isobutoxyphenyl)cyclopropyl)methanamine hydrochloride

Chemical Property of CyclopropaneMethanaMine, 2-[2-(2-Methylpropoxy)phenyl]-, hydrochloride (1:1), (1R,2R)-rel-

Chemical Property:

• PSA: 35.25000
• LogP: 4.28590

Purity/Quality:

99.3% ^*data from raw suppliers

trans-(2-(2-isobutoxyphenyl)cyclopropyl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CyclopropaneMethanaMine, 2-[2-(2-Methylpropoxy)phenyl]-, hydrochloride (1:1), (1R,2R)-rel-

There total 10 articles about CyclopropaneMethanaMine, 2-[2-(2-Methylpropoxy)phenyl]-, hydrochloride (1:1), (1R,2R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H29NO3 → trans-[2-(2-isobutyloxyphenyl)cyclopropyl]methylamine hydrochloride (1344119-14-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 48h;

DOI:10.1021/ml200206z

Reference yield:

trans-(2-(2-methoxyphenyl)cyclopropyl)methanamine → trans-[2-(2-isobutyloxyphenyl)cyclopropyl]methylamine hydrochloride (1344119-14-7)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 20 °C

2: methanol; boron tribromide / dichloromethane / -78 - 20 °C

3: triethylamine / dichloromethane / 0.5 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation

5: hydrogenchloride / diethyl ether; water / 48 h / 20 °C

With hydrogenchloride; methanol; boron tribromide; potassium carbonate; triethylamine; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ml200206z

Reference yield:

trans-[2-(2-hydroxyphenyl)cyclopropyl]methylamine → trans-[2-(2-isobutyloxyphenyl)cyclopropyl]methylamine hydrochloride (1344119-14-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation

3: hydrogenchloride / diethyl ether; water / 48 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ml200206z

upstream raw materials:

C₁₂H₁₅NO₃

ortho-anisaldehyde

Refernces