Technology Process of 2-Methyl-4-(trifluoromethoxy)benzoyl chloride 95+%
There total 4 articles about 2-Methyl-4-(trifluoromethoxy)benzoyl chloride 95+% which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxalyl dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 0 - 25 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: isopentyl nitrite; tetrabutylammomium bromide; p-toluenesulfonic acid monohydrate; copper(ll) bromide / acetonitrile / 12 h / 20 °C
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; carbon monoxide; triethylamine / 16 h / 80 °C / 2585.81 Torr
3: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 25 °C
4: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 0 - 25 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; carbon monoxide; p-toluenesulfonic acid monohydrate; tetrabutylammomium bromide; water; triethylamine; sodium hydroxide; copper(ll) bromide; isopentyl nitrite;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; carbon monoxide; triethylamine / 16 h / 80 °C / 2585.81 Torr
2: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 25 °C
3: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 0 - 25 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; carbon monoxide; water; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
