Technology Process of benzyl 5-(hydroxymethyl)-6-iodo-1,3-dihydro-2H-isoindole-2-carboxylate
There total 7 articles about benzyl 5-(hydroxymethyl)-6-iodo-1,3-dihydro-2H-isoindole-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-benzyl 5-methyl 6-iodo-1,3-dihydro-2H-isoindole-2.5-dicarboxylate;
With
lithium triethylborohydride;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
With
hydrogenchloride; water;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid; nitric acid / water / 0.5 h / 0 °C
2.1: dichloromethane / 1 h / 20 °C
3.1: tin(ll) chloride / N,N-dimethyl-formamide
4.1: Iodine monochloride; sodium hydrogencarbonate / methanol; dichloromethane / 0.5 h
5.1: 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; triethylamine / palladium diacetate / methanol; acetonitrile / 4.08 h / 70 °C
6.1: tert.-butylnitrite / chloroform / 0.33 h
6.2: 20 - 80 °C
7.1: lithium triethylborohydride / tetrahydrofuran / 2 h / -78 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; tert.-butylnitrite; sulfuric acid; nitric acid; Iodine monochloride; lithium triethylborohydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; tin(ll) chloride;
palladium diacetate;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tin(ll) chloride / N,N-dimethyl-formamide
2.1: Iodine monochloride; sodium hydrogencarbonate / methanol; dichloromethane / 0.5 h
3.1: 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; triethylamine / palladium diacetate / methanol; acetonitrile / 4.08 h / 70 °C
4.1: tert.-butylnitrite / chloroform / 0.33 h
4.2: 20 - 80 °C
5.1: lithium triethylborohydride / tetrahydrofuran / 2 h / -78 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; tert.-butylnitrite; Iodine monochloride; lithium triethylborohydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; tin(ll) chloride;
palladium diacetate;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
