4-(chloromethyl)-1,3-thiazole-2-carbonyl Chloride

Base Information

Chemical Name:4-(chloromethyl)-1,3-thiazole-2-carbonyl Chloride
CAS No.:200418-16-2
Molecular Formula:C₅H₃Cl₂NOS
Molecular Weight:196.057
Hs Code.:
DSSTox Substance ID:DTXSID30442398
Wikidata:Q82259652
Mol file:200418-16-2.mol

Synonyms:200418-16-2;2-Thiazolecarbonylchloride,4-(chloromethyl)-(9CI);4-(chloromethyl)-1,3-thiazole-2-carbonyl Chloride;SCHEMBL1118859;DTXSID30442398;YYRHYWJJIKIDHM-UHFFFAOYSA-N;AKOS032961133

Suppliers and Price of 4-(chloromethyl)-1,3-thiazole-2-carbonyl Chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-(chloromethyl)-1,3-thiazole-2-carbonyl Chloride

Chemical Property:

PSA：58.20000
LogP:2.26090
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:194.9312403
Heavy Atom Count:10
Complexity:144

Purity/Quality:: 85.0-99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(N=C(S1)C(=O)Cl)CCl

Technology Process of 4-(chloromethyl)-1,3-thiazole-2-carbonyl Chloride

There total 1 articles about 4-(chloromethyl)-1,3-thiazole-2-carbonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100960-16-5
4-(chloromethyl)thiazole-2-carboxylic acid-ethyl ester

: 200418-16-2
4-Chloromethyl-thiazole-2-carbonyl chloride

Guidance literature:: With potassium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; Yield given. Multistep reaction; 1.) EtOH, RT, 1 h, 2.) CH₂Cl₂, 1 h;
DOI:10.1021/jm970389+

Reference yield:

: 200418-16-2
4-Chloromethyl-thiazole-2-carbonyl chloride

: 6-(4-Fluoro-phenyl)-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-thiazole-2-carbonyl]-indole-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 15 min, 2.) CH₂Cl₂, RT, 2.5 h

2: 1.) NaBr, 2.) DMPU / 1.) THF, RT, 1 h, 2.) THF, RT, 3 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; aluminium trichloride; sodium bromide;
DOI:10.1021/jm970389+