Tetrahydro-3-oxo-2H-pyran-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: Tetrahydro-3-oxo-2H-pyran-4-carboxylic acid ethyl ester
• CAS No.: 388109-26-0
• Molecular Formula: C8H12O4
• Molecular Weight: 172
• Hs Code.: 2932999099
• Mol file: 388109-26-0.mol

Synonyms:Tetrahydro-3-oxo-2H-pyran-4-carboxylic acid ethyl ester;ethyl tetrahydro-3-oxo-2H-pyran-4-carboxylate

Chemical Property of Tetrahydro-3-oxo-2H-pyran-4-carboxylic acid ethyl ester

Chemical Property:

• Boiling Point: 265℃
• PKA: 10.55±0.20(Predicted)
• Flash Point: 114℃
• PSA: 52.60000
• Density: 1.162
• LogP: 0.15510

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl3-Oxotetrahydro-2H-pyran-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-3-oxo-2H-pyran-4-carboxylic acid ethyl ester

There total 2 articles about Tetrahydro-3-oxo-2H-pyran-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-ethoxycarbonylmethoxy-butyric acid ethyl ester (388109-23-7) → ethyl 3-oxotetrahydro-2H-pyran-4-carboxylate (388109-26-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; toluene;

Reference yield:

methyl 4-(2-ethoxy-2-oxoethoxy) butanoate → ethyl 3-oxotetrahydro-2H-pyran-4-carboxylate (388109-26-0) + methyl 3-oxotetrahydro-2H-pyran-4-carboxylate (1787263-94-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; toluene; at 20 ℃; for 18h; Overall yield = 54 %; Overall yield = 2.0 g;

DOI:10.1021/acsmedchemlett.8b00274

Reference yield: 96.0%

ethyl 3-oxotetrahydro-2H-pyran-4-carboxylate (388109-26-0) + tert-butyl 2-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate → tert-butyl 2-(9-hydroxy-7,8-dihydro-5H-pyrano[3,4-d]pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carboxylate

Guidance literature:

With acetic acid; In ethanol; for 2h; Reflux;

upstream raw materials:

4-ethoxycarbonylmethoxy-butyric acid ethyl ester

Downstream raw materials:

C₁₄H₁₉NO₃

C₂₆H₃₃FN₂O₂

C₁₈H₂₅FN₂O₂

C₁₈H₂₇FN₂O

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 388109-26-0 Tetrahydro-3-oxo-2H-pyran-4-carboxylic acid ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send