[(2E)-3-Methoxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene](4-methoxyphenyl)acetic acid methyl ester

Base Information

Chemical Name:[(2E)-3-Methoxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene](4-methoxyphenyl)acetic acid methyl ester
CAS No.:22628-24-6
Molecular Formula:C21H18O6
Molecular Weight:366.37
Hs Code.:
Mol file:22628-24-6.mol

Synonyms:[(2E)-3-Methoxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene](4-methoxyphenyl)acetic acid methyl ester;4-Methoxy-α-[(2E)-3-methoxy-5-oxo-4-phenylfuran-2(5H)-ylidene]benzeneacetic acid methyl ester

Suppliers and Price of [(2E)-3-Methoxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene](4-methoxyphenyl)acetic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(2E)-3-Methoxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene](4-methoxyphenyl)acetic acid methyl ester

Chemical Property:

PSA：71.06000
LogP:3.19380

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [(2E)-3-Methoxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene](4-methoxyphenyl)acetic acid methyl ester

There total 13 articles about [(2E)-3-Methoxy-4-phenyl-5-oxo-2,5-dihydrofuran-2-ylidene](4-methoxyphenyl)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 22628-20-2
(E)-4-hydroxy-5-(α-methoxycarbonyl-4-methoxybenzylidene)-3-phenylfuran-2(5H)-one

: 22628-24-6
(E)-4-methoxy-5-(α-methoxycarbonyl-4-methoxybenzylidene)-3-phenylfuran-2(5H)-one

Guidance literature:: In diethyl ether; at 0 ℃; for 3h;

Reference yield: 86.0%

methyl {3-methoxy-5-oxo-4-[(trifluoromethylsulfonyl)oxy]furan-2(5H)-ylidene}(4-methoxyphenyl)acetate: 561015-10-9
methyl {3-methoxy-5-oxo-4-[(trifluoromethylsulfonyl)oxy]furan-2(5H)-ylidene}(4-methoxyphenyl)acetate

: 98-80-6
phenylboronic acid

: 22628-24-6
(E)-4-methoxy-5-(α-methoxycarbonyl-4-methoxybenzylidene)-3-phenylfuran-2(5H)-one

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 4h; Heating;
DOI:10.1002/anie.200390332

Reference yield:

methyl [4-hydroxy-3-methoxy-5-oxofuran-2(5H)-ylidene](4-methoxyphenyl)acetate: 561015-13-2
methyl [4-hydroxy-3-methoxy-5-oxofuran-2(5H)-ylidene](4-methoxyphenyl)acetate

: 22628-24-6
(E)-4-methoxy-5-(α-methoxycarbonyl-4-methoxybenzylidene)-3-phenylfuran-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / pyridine / CH₂Cl₂ / 4 h / -78 - 20 °C

2: 86 percent / K₃PO₄ / Pd(PPh₃)4 / dioxane / 4 h / Heating

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane;
DOI:10.1002/ejoc.200500837