(1-Methyl-3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-YL)methanol

Base Information

Chemical Name:(1-Methyl-3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-YL)methanol
CAS No.:639784-65-9
Molecular Formula:C₁₂H₁₁F₃N₂O
Molecular Weight:256.227
Hs Code.:

Synonyms:639784-65-9;(1-METHYL-3-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOL-5-YL)METHANOL;[2-methyl-5-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methanol;[2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-methanol;SCHEMBL4685144;1H-Pyrazole-5-methanol, 1-methyl-3-[4-(trifluoromethyl)phenyl]-;MFCD17926173;AS-35449;CS-0061734;FT-0733536;A917619

Suppliers and Price of (1-Methyl-3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-YL)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (1-Methyl-3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-YL)methanol

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:256.08234746
Heavy Atom Count:18
Complexity:277

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=CC(=N1)C2=CC=C(C=C2)C(F)(F)F)CO

Technology Process of (1-Methyl-3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-YL)methanol

There total 5 articles about (1-Methyl-3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-5-YL)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.29%

: 864426-78-8
2-methyl-5-(4-trifluoromethyl-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester

: 639784-65-9
{1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 30h;

Reference yield: 75.0%

: 1202942-17-3
1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole

: 639784-65-9
{1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}methanol

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 80 ℃; for 16h;
DOI:10.1021/jm901378u

Reference yield:

: 639784-60-4
3-(4-trifluoromethylphenyl)-1H-pyrazole-5-carboxylic acid ethyl ester

: 639784-65-9
{1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}methanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 0.33 h / 25 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / 25 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetone;