1,2-Piperidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl) ester, (2R)-

Base Information

• Chemical Name: 1,2-Piperidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl) ester, (2R)-
• CAS No.: 1273565-12-0
• Molecular Formula: C11H17NO5
• Molecular Weight: 243.25638
• Mol file: 1273565-12-0.mol

Synonyms:1,2-Piperidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl) ester, (2R)-;(R)-1-(tert-Butoxycarbonyl)-5-oxopiperidine-2-carboxylic acid;(2R)-1-N-Boc-5-oxo-piperidine-2-carboxylic acid;(R)-1-(Boc)-5-oxopiperidine-2-carboxylic acid

Chemical Property of 1,2-Piperidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl) ester, (2R)-

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(2r)-1-N-Boc-5-Oxo-Piperidine-2-CarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Piperidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl) ester, (2R)-

There total 2 articles about 1,2-Piperidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl) ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(±)-5-oxopiperidine-2-carboxylic acid (146467-21-2,789448-80-2) + di-tert-butyl dicarbonate (24424-99-5) → (±)-1-tert-butoxycarbonyl-5-oxopiperidine-2-carboxylic acid (1273565-12-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

1-(tert-butyl) 2-methyl (S)-5-oxopiperidine-1,2-dicarboxylate (915976-31-7) → (2S)-1-(tert-butoxycarbonyl)-5-oxopiperidine-2-carboxylic acid (915976-41-9,1273565-12-0)

Guidance literature:

1-(tert-butyl) 2-methyl (S)-5-oxopiperidine-1,2-dicarboxylate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 85 ℃; for 2.5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

(±)-1-tert-butoxycarbonyl-5-oxopiperidine-2-carboxylic acid (1273565-12-0) → (±)-methyl 1-tert-butoxycarbonyl-5,5-difluoropiperidine-2-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; methanol / 1 h / 0 - 20 °C

2: triethylamine; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; triethylamine tris(hydrogen fluoride) / dichloromethane / 20 °C

With triethylamine tris(hydrogen fluoride); triethylamine; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In methanol; dichloromethane; toluene;

upstream raw materials:

1-(tert-butyl) 2-methyl (S)-5-oxopiperidine-1,2-dicarboxylate

(±)-5-oxopiperidine-2-carboxylic acid

di-tert-butyl dicarbonate

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