6-METHYL-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID

Base Information

• Chemical Name: 6-METHYL-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID
• CAS No.: 18060-34-9
• Molecular Formula: C18H15NO2
• Molecular Weight: 277.3172
• Hs Code.: 2933499090
• Mol file: 18060-34-9.mol

Synonyms:6-METHYL-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID;6-methyl-2-(4-methylphenyl)-4-quinolinecarboxylic acid;6-methyl-2-(4-methylphenyl)cinchoninic acid;Oprea1_086732;STK253080

Chemical Property of 6-METHYL-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID

Chemical Property:

• PSA: 50.19000
• LogP: 4.21680

Purity/Quality:

98%min ^*data from raw suppliers

6-Methyl-2-(4-methylphenyl)quinoline-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHYL-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID

There total 5 articles about 6-METHYL-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-methyl-benzaldehyde (104-87-0) + p-toluidine (106-49-0,12221-03-3) + 2-oxo-propionic acid (127-17-3) → 6-methyl-2-p-tolyl-quinoline-4-carboxylic acid (18060-34-9)

Guidance literature:

With ytterbium perfluorooctanoate; In water; for 3h; Reflux;

DOI:10.1016/j.jfluchem.2009.01.002

Reference yield:

5-methyl-indole-2,3-dione (608-05-9) + para-methylacetophenone (122-00-9) → 6-methyl-2-p-tolyl-quinoline-4-carboxylic acid (18060-34-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 85 ℃;

DOI:10.1016/j.bmc.2017.09.004

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 6-methyl-2-p-tolyl-quinoline-4-carboxylic acid (18060-34-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium sulfate; hydrogenchloride / water / 2 h / Heating

2: sulfuric acid / 60 - 90 °C

3: potassium hydroxide / ethanol / 85 °C

With hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; potassium hydroxide; In ethanol; water; 2: |Sandmeyer Reaction / 3: |Pfitzinger Quinoline Synthesis;

DOI:10.1016/j.bmc.2017.09.004

upstream raw materials:

4-methyl-benzaldehyde

p-toluidine

2-oxo-propionic acid

2-hydroxyimino-N-p-tolyl-acetamide

Downstream raw materials:

C₁₈H₁₄ClNO

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