α-Tocopherol-[D6] (Vitamin E-[D6])

Base Information

• Chemical Name: α-Tocopherol-[D6] (Vitamin E-[D6])
• CAS No.: 113892-08-3
• Molecular Formula: C29H50O2
• Molecular Weight: 430.72
• Mol file: 113892-08-3.mol

Synonyms:α-Tocopherol-[D6] (Vitamin E-[D6])

Chemical Property of α-Tocopherol-[D6] (Vitamin E-[D6])

Chemical Property:

• Boiling Point: 200-220°C/1 mmHg(lit.)
• Flash Point: 9℃
• PSA: 29.46000
• Density: 0.963 g/mL at 25 °C
• LogP: 8.84020

Purity/Quality:

99% ^*data from raw suppliers

α-Tocopherol-d6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Labelled α-Tocopherol (T526125). Most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils.

Technology Process of α-Tocopherol-[D6] (Vitamin E-[D6])

There total 1 articles about α-Tocopherol-[D6] (Vitamin E-[D6]) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

paraformaldehyde-d2 (1664-98-8,43094-80-0) + delta tocopherol (119-13-1,78656-14-1) → [D6]α-tocopherol (113892-08-3)

Guidance literature:

With diclazuril; water-d2; tin(ll) chloride; In di-isopropyl ether; at 65 ℃; for 4h;

DOI:10.1016/j.tet.2004.11.047

Reference yield:

[D6]α-tocopherol (113892-08-3) → C28H45(2)H3O2

Guidance literature:

Multi-step reaction with 6 steps

1: Br₂ / hexane / 3 h / 20 °C

2: AcOH; H₂SO₄ / CH₂Cl₂ / 20 °C

3: N-methylmorpholine N-oxide / acetonitrile / 5 h / 20 °C

4: NH₂SO₃H; NaClO₂ / dioxane; H₂O / 0.83 h / 20 °C

5: KOH / methanol / 2 h / 50 °C

6: 3 h / 170 °C

With potassium hydroxide; sodium chlorite; sulfuric acid; aminosulfonic acid; bromine; acetic acid; 4-methylmorpholine N-oxide; In 1,4-dioxane; methanol; hexane; dichloromethane; water; acetonitrile;

DOI:10.1016/j.tet.2004.11.047

upstream raw materials:

paraformaldehyde-d2

delta tocopherol

Refernces

• 1、 Mazzini, Francesco,Netscher, Thomas,Salvadori, Piero. "Easy route to labeled and unlabeled R,R,R-γ-tocopherol by aryl demethylation of α-homologues". . p. 813 - 817. Retrieved 2005.