Methyl 1-Methyl-2-oxopiperidine-3-carboxylate

Base Information

• Chemical Name: Methyl 1-Methyl-2-oxopiperidine-3-carboxylate
• CAS No.: 101327-98-4
• Molecular Formula: C8H13NO3
• Molecular Weight: 171.19372
• Mol file: 101327-98-4.mol

Synonyms:Methyl 1-Methyl-2-oxopiperidine-3-carboxylate;1-Methyl-2-oxo-3-piperidinecarboxylic acid methyl ester

Chemical Property of Methyl 1-Methyl-2-oxopiperidine-3-carboxylate

Chemical Property:

• PSA: 46.61000
• LogP: -0.03430

Purity/Quality:

97% ^*data from raw suppliers

Methyl1-Methyl-2-oxopiperidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-Methyl-2-oxopiperidine-3-carboxylate

There total 2 articles about Methyl 1-Methyl-2-oxopiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-methylpiperidin-2-one (931-20-4) + methyl chloroformate (79-22-1) → (±)-methyl 1-methyl-2-oxopiperidine-3-carboxylate (101327-98-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 2h;

DOI:10.1016/S0040-4039(00)89191-1

Reference yield: 42.0%

1-methylpiperidin-2-one (931-20-4) + carbonic acid dimethyl ester (616-38-6) → (±)-methyl 1-methyl-2-oxopiperidine-3-carboxylate (101327-98-4)

Guidance literature:

1-methylpiperidin-2-one; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

carbonic acid dimethyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 4h;

DOI:10.1016/j.tet.2018.06.021

Reference yield:

nitrostyrene (5153-67-3) + (±)-methyl 1-methyl-2-oxopiperidine-3-carboxylate (101327-98-4) → methyl (3S)-1-methyl-3-[(1S)-2-nitro-1-phenylethyl]-2-oxopiperidine-3-carboxylate + methyl 1-methyl-3-[2-nitro-1-phenylethyl]-2-oxopiperidine-3-carboxylate + methyl 1-methyl-3-[2-nitro-1-phenylethyl]-2-oxopiperidine-3-carboxylate

Guidance literature:

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(2R)-1,1-diphenyl-3-{[tris(4-methoxyphenyl)-λ⁵-phosphanylidene]amino}propan-2-yl]thiourea; In tetrahydrofuran; at -20 ℃; for 22h; Overall yield = 78 %; Overall yield = 50 mg; stereoselective reaction;

DOI:10.1016/j.tet.2018.06.021

upstream raw materials:

1-methylpiperidin-2-one

methyl chloroformate

carbonic acid dimethyl ester

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