(S)-3-PHENYL PIPERIDINE

Base Information

• Chemical Name: (S)-3-PHENYL PIPERIDINE
• CAS No.: 1258940-00-9
• Molecular Formula: C11H15N
• Molecular Weight: 161.24
• Mol file: 1258940-00-9.mol

Synonyms:(S)-3-PHENYL PIPERIDINE;(S)-3-Phenyl-piperidine hydrochloride

Chemical Property of (S)-3-PHENYL PIPERIDINE

Chemical Property:

• Melting Point: 178.2-178.4 °C
• PSA: 12.03000
• LogP: 3.28440

Purity/Quality:

95-99% ^*data from raw suppliers

(S)-3-Phenyl-piperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-PHENYL PIPERIDINE

There total 5 articles about (S)-3-PHENYL PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(R(S),S)-N-tert-butanesulfinyl-3-phenylpiperidine (1258939-88-6) → (S)-3-phenylpiperidine hydrochloride (1258940-00-9,450416-58-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; optical yield given as %ee;

DOI:10.1021/jo1020807

Reference yield:

(R(S),S)-methyl N-tert-butanesulfinyl-5-chloro-2-phenylpentanimidate → (S)-3-phenylpiperidine hydrochloride (1258940-00-9,450416-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / Reflux

2: sodium hydride / dimethyl sulfoxide / 80 °C

3: hydrogenchloride / 1,4-dioxane; diethyl ether / 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dimethyl sulfoxide;

DOI:10.1021/jo1020807

Reference yield:

(R(S))-methyl N-tert-butanesulfinylphenylacetimidate (817576-00-4) → (S)-3-phenylpiperidine hydrochloride (1258940-00-9,450416-58-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: -78 - 0 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / Reflux

3.1: sodium hydride / dimethyl sulfoxide / 80 °C

4.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dimethyl sulfoxide;

DOI:10.1021/jo1020807

upstream raw materials:

(R(S),S)-N-tert-butanesulfinyl-5-chloro-2-phenylpentylamine

(R(S))-methyl N-tert-butanesulfinylphenylacetimidate

(R(S),S)-N-tert-butanesulfinyl-3-phenylpiperidine

benzeneacetic acid methyl ester

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