2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL

Base Information

Chemical Name:2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL
CAS No.:647862-98-4
Molecular Formula:C₈H₈F₃N₃O
Molecular Weight:219.166
Hs Code.:2933990090
Mol file:647862-98-4.mol

Synonyms:2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL

Suppliers and Price of 2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol 95+%
1g
$ 550.00

American Custom Chemicals Corporation
2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL 95.00%
5MG
$ 497.30

American Custom Chemicals Corporation
2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL 95.00%
250MG
$ 651.00

Alichem
2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol
1g
$ 585.00

Total 3 raw suppliers

Chemical Property of 2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL

Chemical Property:

PSA：58.04000
LogP:1.17550

Purity/Quality:

98%min ^*data from raw suppliers

2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL

There total 2 articles about 2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 647862-97-3
7-benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol

: 647862-98-4
2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol

Guidance literature:: With hydrogen; 20 % Pd(OH)2/C; In methanol; for 20h; under 2585.81 Torr;

Reference yield:

: 52763-21-0
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

: 647862-98-4
2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol / 17.25 h / 20 - 80 °C

2: hydrogen / 20 % Pd(OH)2/C / methanol / 20 h / 2585.81 Torr

With hydrogen; sodium ethanolate; 20 % Pd(OH)2/C; In methanol; ethanol;

Reference yield:

: 647862-98-4
2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol

: 1274804-59-9
4-[4-((R)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonyl-benzenesulfonylamino]-2-trifluoromethyl-5,8-dihydro-6Hpyrido[3,4-d]pyrimidine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: tetrachloromethane; triphenylphosphine / dichloromethane / 3 h / 20 - 70 °C / Inert atmosphere

3: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 110 - 150 °C / Inert atmosphere

With tetrachloromethane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; triphenylphosphine; DavePhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/ml300321d