METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE

Base Information

Chemical Name:METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE
CAS No.:1228543-08-5
Molecular Formula:C₁₁H₁₂F₃NO₂
Molecular Weight:247.217
Hs Code.:
Mol file:1228543-08-5.mol

Synonyms:METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE

Suppliers and Price of METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE

There total 5 articles about METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1271792-83-6
C₁₉H₂₀F₃NO₂

: 1228543-08-5
(R)-methyl 3-amino-3-(4-(trifluoromethyl)phenyl)propanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; under 11400.8 Torr; Inert atmosphere;
DOI:10.1039/c0ob00570c

Reference yield:

: 1271792-68-7
(R,Z)-methyl 3-(1-phenylethylamino)-3-(4-(trifluoromethyl)phenyl)acrylate

: 1228543-08-5
(R)-methyl 3-amino-3-(4-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: C₁₆H₁₇ClN₂O₂; trichlorosilane / dichloromethane / 18 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 11400.8 Torr / Inert atmosphere

With C₁₆H₁₇ClN₂O₂; palladium 10% on activated carbon; trichlorosilane; hydrogen; In methanol; dichloromethane;
DOI:10.1039/c0ob00570c

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1228543-08-5
(R)-methyl 3-amino-3-(4-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / toluene / Reflux; Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: benzene / Reflux; Inert atmosphere; Molecular sieve

3.1: C₁₆H₁₇ClN₂O₂; trichlorosilane / dichloromethane / 18 h / 0 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 11400.8 Torr / Inert atmosphere

With C₁₆H₁₇ClN₂O₂; palladium 10% on activated carbon; trichlorosilane; hydrogen; sodium hydride; In methanol; dichloromethane; toluene; benzene;
DOI:10.1039/c0ob00570c