Technology Process of METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE
There total 5 articles about METHYL (3R)-3-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOATE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 16h;
under 11400.8 Torr;
Inert atmosphere;
DOI:10.1039/c0ob00570c
- Guidance literature:
-
Multi-step reaction with 2 steps
1: C16H17ClN2O2; trichlorosilane / dichloromethane / 18 h / 0 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 11400.8 Torr / Inert atmosphere
With
C16H17ClN2O2; palladium 10% on activated carbon; trichlorosilane; hydrogen;
In
methanol; dichloromethane;
DOI:10.1039/c0ob00570c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / toluene / Reflux; Inert atmosphere
1.2: Reflux; Inert atmosphere
2.1: benzene / Reflux; Inert atmosphere; Molecular sieve
3.1: C16H17ClN2O2; trichlorosilane / dichloromethane / 18 h / 0 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 11400.8 Torr / Inert atmosphere
With
C16H17ClN2O2; palladium 10% on activated carbon; trichlorosilane; hydrogen; sodium hydride;
In
methanol; dichloromethane; toluene; benzene;
DOI:10.1039/c0ob00570c