Technology Process of 2,3,6,7-Tetrahydro-4-oxepinecarboxylic acid ethyl ester
There total 5 articles about 2,3,6,7-Tetrahydro-4-oxepinecarboxylic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
DOI:10.1002/anie.201301341
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / 20 °C
With
1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201301341
- Guidance literature:
-
Multi-step reaction with 4 steps
1: boron trifluoride diethyl etherate / dichloromethane; diethyl ether / 1.5 h / -30 °C
2: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C
3: triethylamine / dichloromethane / 5 h / 0 - 20 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / 20 °C
With
sodium tetrahydroborate; boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1002/anie.201301341
