1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate

Base Information

• Chemical Name: 1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate
• CAS No.: 1256815-07-2
• Molecular Formula: C15H29N3O4
• Molecular Weight: 315.41
• Mol file: 1256815-07-2.mol

Synonyms:1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate;Di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate

Chemical Property of 1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate

Chemical Property:

• PSA: 85.10000
• LogP: 2.37760
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

1,4-Di-Tert-Butyl2-(Aminomethyl)Piperazine-1,4-Dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate

There total 2 articles about 1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate (1256815-06-1) → di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate (1256815-07-2,1808248-63-6,1932411-32-9)

Guidance literature:

di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate; With methylamine; In ethanol; for 4h; Reflux;

With hydrogenchloride; In water; pH=3;

With sodium hydroxide; In water; pH=10;

DOI:10.1016/j.ejmech.2010.08.002

Reference yield:

2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester (143540-05-0) → di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate (1256815-07-2,1808248-63-6,1932411-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 10 °C

2: methylamine / ethanol / 4 h / Reflux

With di-isopropyl azodicarboxylate; triphenylphosphine; methylamine; In tetrahydrofuran; ethanol; 2: Mitsunobu reaction;

DOI:10.1080/00397911.2010.525774

Reference yield:

di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate (1256815-07-2,1808248-63-6,1932411-32-9) → hexahydro-2-(4-fluorophenyl)-imidazo[1,5-a]pyrazin-3-one (1256815-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate / toluene / 48 h / Inert atmosphere; Reflux

3: hydrogenchloride / diethyl ether; dichloromethane

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; sodium t-butanolate; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; mineral oil; 2: Buchwald-Hartwig coupling reaction;

DOI:10.1080/00397911.2010.525774

upstream raw materials:

di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate

2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester

Downstream raw materials:

tert-butyl 3-oxo-1,2,5,6,8,8a-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate

hexahydro-2-(4-trifluoromethylphenyl)-imidazo[1,5-a]pyrazin-3-one

2-benzylhexahydroimidazo[1,5-a]pyrazin-3(2H)-one

tert-butyl 2-(4-(trifluoromethyl)phenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1256815-07-2 1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send