2-(PhenylMethoxy)-acetic Acid Hydrazide

Base Information

• Chemical Name: 2-(PhenylMethoxy)-acetic Acid Hydrazide
• CAS No.: 39256-35-4
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Hs Code.: 2928000090
• Mol file: 39256-35-4.mol

Synonyms:2-(PhenylMethoxy)-acetic Acid Hydrazide;2-(Benzyloxy)acetic Acid Hydrazide;Benzyloxyacetic Acid Hydrazide;N-AMino-2-(phenylMethoxy)acetaMide;2-(benzyloxy)acetohydrazide

Chemical Property of 2-(PhenylMethoxy)-acetic Acid Hydrazide

Chemical Property:

• Boiling Point: 366.9±25.0 °C(Predicted)
• PKA: 12.42±0.35(Predicted)
• PSA: 67.84000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 1.73370
• Solubility.: Dichloromethane

Purity/Quality:

99% ^*data from raw suppliers

2-(Phenylmethoxy)-aceticAcidHydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(PhenylMethoxy)-acetic Acid Hydrazide can be used in the preparation of boronate ester thrombin inhibitors.

Technology Process of 2-(PhenylMethoxy)-acetic Acid Hydrazide

There total 5 articles about 2-(PhenylMethoxy)-acetic Acid Hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl benzyloxyacetate (32122-09-1) → benzyloxyacetic acid hydrazide (39256-35-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1021/jm3013213

Reference yield: 70.0%

benzyloxyacetic acid (30379-55-6) → benzyloxyacetic acid hydrazide (39256-35-4)

Guidance literature:

benzyloxyacetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 ℃; for 1h;

With hydrazine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

Benzyloxyacetyl chloride (19810-31-2) → benzyloxyacetic acid hydrazide (39256-35-4)

Guidance literature:

With hydrazine; In tetrahydrofuran; at 0 - 20 ℃; for 18.5h;

upstream raw materials:

methyl 2-(benzyloxy)acetate

Benzyloxyacetyl chloride

ethyl benzyloxyacetate

benzyloxyacetic acid

Downstream raw materials:

3-Benzyloxymethyl-5-phenethyl-1H-[1,2,4]triazole

5-Benzyl-3-benzyloxymethyl-1H-[1,2,4]triazole

2-benzyloxymethyl-1,3,4-oxadiazole

C₁₇H₁₅F₃N₂O₃