(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

Base Information

Chemical Name:(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate
CAS No.:1373431-65-2
Molecular Formula:C26H22F2N6O4S
Molecular Weight:552.561
Hs Code.:
Mol file:1373431-65-2.mol

Synonyms:(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

Suppliers and Price of (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Talazoparib（BMN-673）tosylate >98%
1 g
$ 1800.00

DC Chemicals
Talazoparib（BMN-673）tosylate >98%
250 mg
$ 950.00

DC Chemicals
Talazoparib（BMN-673）tosylate >98%
100 mg
$ 500.00

ChemScene
Talazoparibtosylate 99.72%
200mg
$ 550.00

ChemScene
Talazoparibtosylate 99.72%
10mg
$ 100.00

ChemScene
Talazoparibtosylate 99.72%
5mg
$ 70.00

ChemScene
Talazoparibtosylate 99.72%
100mg
$ 400.00

ChemScene
Talazoparibtosylate 99.72%
50mg
$ 250.00

Biosynth Carbosynth
Talazoparib tosylate
10 mg
$ 210.00

Biosynth Carbosynth
Talazoparib tosylate
50 mg
$ 425.00

Total 17 raw suppliers

Chemical Property of (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

Chemical Property:

PSA：154.73000
LogP:4.22080
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Acetone (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Talazoparib（BMN-673）tosylate >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Talazoparib Tosylate is Quinoline derivative used for treating non-small cell lung cancer.

Technology Process of (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

There total 1 articles about (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1207456-01-6
((11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5⁽¹³⁾,6,8-tetraen-4-one)

: 104-15-4
toluene-4-sulfonic acid

: 1373431-65-2
(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

Guidance literature:: In dichloromethane; acetonitrile; at 25 - 40 ℃; for 0.0180556h; Product distribution / selectivity;

Reference yield:

: 1373431-65-2
(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

: 1207456-01-6
((11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5⁽¹³⁾,6,8-tetraen-4-one)

Guidance literature:: In acetone; Product distribution / selectivity;

Reference yield:

: 1373431-65-2
(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

: 1373329-48-6
C₁₉H₁₄F₂N₆O*ClH

Guidance literature:: Multi-step reaction with 2 steps

1: acetone

2: hydrogenchloride / tetrahydrofuran / 5 - 60 °C

With hydrogenchloride; In tetrahydrofuran; acetone;