3-Bromo-2-chloroanisole

Base Information

• Chemical Name: 3-Bromo-2-chloroanisole
• CAS No.: 174913-11-2
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.47894
• Hs Code.: 2909309090
• Mol file: 174913-11-2.mol

Synonyms:3-Bromo-2-chloroanisole;1-Bromo-2-chloro-3-methoxybenzene

Chemical Property of 3-Bromo-2-chloroanisole

Chemical Property:

• Boiling Point: 241.6±20.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.564±0.06 g/cm3(Predicted)
• LogP: 3.11110
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-2-chloro-3-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-2-chloroanisole

There total 2 articles about 3-Bromo-2-chloroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-methoxynitrobenzene (3970-39-6) → 3-bromo-2-chloro-anisole (174913-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium chloride; iron / water; ethanol / 12 h / 95 °C

2.1: hydrogen bromide; sodium nitrite / water; acetonitrile / 0.5 h / 20 °C

2.2: 60 °C

With hydrogen bromide; iron; ammonium chloride; sodium nitrite; In ethanol; water; acetonitrile;

DOI:10.1002/chem.201701707

Reference yield:

2-methoxy-6-nitroaniline (16554-45-3) → 3-bromo-2-chloro-anisole (174913-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 0.25 h / 20 °C

1.2: 3 h / 60 °C

2.1: ammonium chloride; iron / water; ethanol / 12 h / 95 °C

3.1: hydrogen bromide; sodium nitrite / water; acetonitrile / 0.5 h / 20 °C

3.2: 60 °C

With hydrogenchloride; hydrogen bromide; iron; ammonium chloride; sodium nitrite; In ethanol; water; acetonitrile;

DOI:10.1002/chem.201701707

Reference yield: 73.0%

3-bromo-2-chloro-anisole (174913-11-2) + (E)-(6-(tert-butoxy)hex-3-en-1-yl)benzene → C23H31ClO2

Guidance literature:

(E)-(6-(tert-butoxy)hex-3-en-1-yl)benzene; With dimethylsulfide borane complex; In water; toluene; at 25 - 60 ℃; for 2h;

3-bromo-2-chloro-anisole; With palladium(II) trifluoroacetate; BH₄^(1-)*C₉H₂₁P*H⁽¹⁺⁾; caesium carbonate; In water; toluene; at 120 ℃; for 48h;

DOI:10.1021/acscatal.0c02755

upstream raw materials:

2-methoxy-6-nitroaniline

2-chloro-3-methoxynitrobenzene