3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

Base Information

Chemical Name:3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
CAS No.:1022150-12-4
Molecular Formula:C22H22N6O
Molecular Weight:386.456
Hs Code.:
Mol file:1022150-12-4.mol

Synonyms:3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine;(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;3-(4-Phenoxy-phenyl)-1-(R)-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine;Btk inhibitor 1 (R enantioMer);ibrutinib N-1;3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyriMidin-4-aMine;Ibrutinib intermeidate N-1;3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Suppliers and Price of 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
10g
$ 845.00

TRC
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
5g
$ 545.00

Medical Isotopes, Inc.
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
500 mg
$ 395.00

Matrix Scientific
3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 97%
5g
$ 864.00

Matrix Scientific
3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 97%
1g
$ 288.00

Crysdot
BtkInhibitor1R-Enantiomer 98+%
25g
$ 582.00

Crysdot
BtkInhibitor1R-Enantiomer 98+%
10g
$ 297.00

ChemScene
IBT6A 99.47%
50mg
$ 1800.00

ChemScene
IBT6A 99.47%
100mg
$ 2520.00

ChemScene
IBT6A 99.47%
5mg
$ 420.00

Total 127 raw suppliers

Chemical Property of 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

Chemical Property:

Boiling Point:626.3±55.0 °C(Predicted)
PKA:9.00±0.10(Predicted)
PSA：90.88000
Density:1.39±0.1 g/cm3(Predicted)
LogP:4.70230
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description IBT6A is a Btk kinase inhibitor. 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine is a precurser for the manufacture of ibrutinib.
Uses (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an intermediate used to prepare pyrazolo-pyrimidine compounds as inhibitors of Bruton''s tyrosine kinase. It is also an intermediate for Ibrutinib (I124970) derivatives.

Technology Process of 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

There total 60 articles about 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (3R)-3-[4-(benzyloxycarbonylamino)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylic acid benzyl ester

: 1022150-12-4
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine

Guidance literature:: With palladium on activated charcoal;

Reference yield: 92.1%

: 1419223-01-0
tert-butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo [3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

: 51067-38-0
4-phenoxyphenylboronic acid

: 1022150-12-4
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine

Guidance literature:: tert-butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo [3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate; 4-phenoxyphenylboronic acid; With potassium phosphate; In 1,4-dioxane; water; for 0.333333h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; for 3.08333h; Inert atmosphere; Reflux;

Reference yield: 90.0%

: 51067-38-0
4-phenoxyphenylboronic acid

: C₁₀H₁₃BrN₆*2ClH

: 1022150-12-4
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; for 5h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux;