2-Chloro-5,7-dimethylquinoline-3-carbonitrile

Base Information

Chemical Name:2-Chloro-5,7-dimethylquinoline-3-carbonitrile
CAS No.:917747-10-5
Molecular Formula:C₁₂H₉ClN₂
Molecular Weight:216.67
Hs Code.:2933499090
European Community (EC) Number:809-592-2
DSSTox Substance ID:DTXSID90588988
Wikidata:Q82482045
Mol file:917747-10-5.mol

Synonyms:2-Chloro-5,7-dimethylquinoline-3-carbonitrile;917747-10-5;2-Chloro-5,7-dimethyl-quinoline-3-carbonitrile;AKOS BB-7590;SCHEMBL14125853;DTXSID90588988;MFCD08899072;AKOS000678582;AB49070;MCULE-6000243411;CS-0321830;2-Chloro-5,7-dimethylquinoline-3-carbonitrile, AldrichCPR

Suppliers and Price of 2-Chloro-5,7-dimethylquinoline-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-5,7-dimethylquinoline-3-carbonitrile
500mg
$ 200.00

SynQuest Laboratories
2-Chloro-5,7-dimethylquinoline-3-carbonitrile
5 g
$ 864.00

SynQuest Laboratories
2-Chloro-5,7-dimethylquinoline-3-carbonitrile
1 g
$ 312.00

Sigma-Aldrich
2-Chloro-5,7-dimethylquinoline-3-carbonitrile Aldrich
1g
$ 201.00

Matrix Scientific
2-Chloro-5,7-dimethyl-quinoline-3-carbonitrile
1g
$ 378.00

Crysdot
2-Chloro-5,7-dimethylquinoline-3-carbonitrile 95+%
5g
$ 874.00

Chemenu
2-Chloro-5,7-dimethylquinoline-3-carbonitrile 95%
5g
$ 825.00

Apolloscientific
2-Chloro-5,7-dimethylquinoline-3-carbonitrile
1g
$ 283.00

Apolloscientific
2-Chloro-5,7-dimethylquinoline-3-carbonitrile
5g
$ 783.00

American Custom Chemicals Corporation
2-CHLORO-5,7-DIMETHYLQUINOLINE-3-CARBONITRILE 95.00%
500MG
$ 784.25

Total 3 raw suppliers

Chemical Property of 2-Chloro-5,7-dimethylquinoline-3-carbonitrile

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:386.311°C at 760 mmHg
Flash Point:187.434°C
PSA：36.68000
Density:1.273g/cm³
LogP:3.37668
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:216.0454260
Heavy Atom Count:15
Complexity:283

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-5,7-dimethylquinoline-3-carbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C2C=C(C(=NC2=C1)Cl)C#N)C

Technology Process of 2-Chloro-5,7-dimethylquinoline-3-carbonitrile

There total 4 articles about 2-Chloro-5,7-dimethylquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 482639-32-7
2-chloro-5,7-dimethylquinoline-3-carbaldehyde

: 917747-10-5
2-chloro-5,7-dimethylquinoline-3-carbonitrile

Guidance literature:: 2-chloro-5,7-dimethylquinoline-3-carbaldehyde; With hydroxylamine hydrochloride; triethylamine; In ethanol; for 3h; Reflux;

With hydrogenchloride; In water;

With thionyl chloride; In benzene; for 4h; Inert atmosphere; Reflux;
DOI:10.1124/mol.111.073056

Reference yield:

: 2050-45-5
N-acetyl-3,5-dimethylaniline

: 917747-10-5
2-chloro-5,7-dimethylquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 2 h / Inert atmosphere; Reflux

1.2: 3 h / 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; triethylamine / ethanol / 3 h / Reflux

3.1: thionyl chloride / benzene / 4 h / Inert atmosphere; Reflux

With thionyl chloride; hydroxylamine hydrochloride; triethylamine; trichlorophosphate; In ethanol; benzene; 1.2: Vilsmeier-Haack reaction;
DOI:10.1021/jm201372q

Reference yield:

: 108-69-0
3,5-dimethylaminoaniline

: 917747-10-5
2-chloro-5,7-dimethylquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: trichlorophosphate / 2 h / Inert atmosphere; Reflux

2.2: 3 h / 20 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; triethylamine / ethanol / 3 h / Reflux

4.1: thionyl chloride / benzene / 4 h / Inert atmosphere; Reflux

With thionyl chloride; hydroxylamine hydrochloride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; benzene; 2.2: Vilsmeier-Haack reaction;
DOI:10.1021/jm201372q