Bis(4-fluorobenzyl)aMine, 97%

Base Information

• Chemical Name: Bis(4-fluorobenzyl)aMine, 97%
• CAS No.: 134227-41-1
• Molecular Formula: C14H13F2N
• Molecular Weight: 233.261
• Mol file: 134227-41-1.mol

Synonyms:Bis(4-fluorobenzyl)aMine, 97%

Chemical Property of Bis(4-fluorobenzyl)aMine, 97%

Chemical Property:

• PSA: 12.03000
• LogP: 3.64550
• Storage Temp.: 2-8°C

Purity/Quality:

99.0% Min ^*data from raw suppliers

Bis(4-fluorobenzyl)amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bis(4-fluorobenzyl)aMine, 97%

There total 18 articles about Bis(4-fluorobenzyl)aMine, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

para-fluorobenzylamine (140-75-0) → 1-(4-fluorophenyl)-N-[(4-fluorophenyl)methyl]methanamine (134227-41-1)

Guidance literature:

With γ-Al2O3 supported Pt-Sn; In o-xylene; at 145 ℃; for 24h; under 750.075 Torr; Inert atmosphere;

DOI:10.1002/chem.201101725

Reference yield: 92.0%

4-fluorobenzonitrile (1194-02-1,143234-87-1) → 1-(4-fluorophenyl)-N-[(4-fluorophenyl)methyl]methanamine (134227-41-1)

Guidance literature:

With hydrogen; In toluene; at 90 ℃; for 20h; under 750.075 Torr; chemoselective reaction;

DOI:10.1021/acscatal.0c04379

Reference yield: 90.7%

4-fluorobenzaldehyde (459-57-4) → 4-fluorobenzylic alcohol (459-56-3) + tris(4-fluorobenzyl)amine (932724-63-5) + para-fluorobenzylamine (140-75-0) + benzylamine (100-46-9) + 1-(4-fluorophenyl)-N-[(4-fluorophenyl)methyl]methanamine (134227-41-1)

Guidance literature:

With ammonia; hydrogen; Ni/C catalyst; In water; at 120 ℃; for 17.5h; under 28502.9 - 33753.4 Torr;

upstream raw materials:

4-fluorobenzaldehyde

4-fluorobenzaldoxime

acetaldehyde

propionaldehyde

Downstream raw materials:

N-(4-fluorobenzylidene)-1-(4-fluorophenyl)methanamine

1-(4-fluorobenzyl)-2-(4-fluorophenyl)-1H-1,3-benzimidazole

Refernces

• 1、 Ciattini, Samuele,Eswari, S.,Selvaganapathi, P.,Thirumaran, S.. "Effect of solvent used for crystallization on structure: Synthesis and characterization of bis(N,N-di(4-fluorobenzyl)dithiocarbamato-S,S′)M(II) (M = Cd, Hg) and usage as precursor for CdS nanophotocatalyst". . . Retrieved 2021.
• 2、 Song, Hao,Xiao, Yao,Zhang, Zhuohua,Xiong, Wanjin,Wang, Ren,Guo, Liangcheng,Zhou, Taigang. "Switching Selectivity in Copper-Catalyzed Transfer Hydrogenation of Nitriles to Primary Amine-Boranes and Secondary Amines under Mild Conditions". . p. 790 - 800. Retrieved 2022/01/11.