Technology Process of (1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride
There total 9 articles about (1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; dichloromethane;
at 20 ℃;
for 4h;
- Guidance literature:
-
With
hydrogenchloride;
In
Isopropyl acetate; water;
at 0 - 30 ℃;
for 9h;
Large scale;
DOI:10.1021/acs.oprd.0c00245
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dmap / tetrahydrofuran / 5.25 h / 20 °C
2.1: ozone / dichloromethane / 0.17 h / -78 °C
2.2: -78 - 20 °C
3.1: 2,6-dimethylpyridine; diethylamino-sulfur trifluoride / dichloromethane / 12 h / 10 - 23 °C
4.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 10 h / 50 °C
5.1: 2,6-dimethylpyridine; HATU / acetonitrile / 0.5 h / 25 °C
5.2: 10 - 20 °C
6.1: hydrogenchloride / Isopropyl acetate; isopropyl alcohol / 14 h / 0 - 32 °C
With
2,6-dimethylpyridine; hydrogenchloride; dmap; diethylamino-sulfur trifluoride; water; ozone; HATU; lithium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; Isopropyl acetate; isopropyl alcohol; acetonitrile;
