N-(4-morpholinobutyl)benzofuran-2-carboxamide

Base Information

Chemical Name:N-(4-morpholinobutyl)benzofuran-2-carboxamide
CAS No.:307002-71-7
Molecular Formula:C₁₇H₂₂N₂O₃
Molecular Weight:302.373
Hs Code.:2934999090
European Community (EC) Number:686-940-8
DSSTox Substance ID:DTXSID601024592
Wikidata:Q27076092
ChEMBL ID:CHEMBL116757
Mol file:307002-71-7.mol

Synonyms:CL82198;N-(4-(4-morpholinyl)butyl)-2-benzofurancarboxamide

Suppliers and Price of N-(4-morpholinobutyl)benzofuran-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CL 82198 hydrochloride
10mg
$ 403.00

TRC
CL-82198
5mg
$ 45.00

Tocris
CL82198hydrochloride ≥98%(HPLC)
50
$ 668.00

Tocris
CL82198hydrochloride ≥98%(HPLC)
10
$ 159.00

Sigma-Aldrich
CL-82198 ≥98% (HPLC), powder
5mg
$ 72.70

Sigma-Aldrich
CL-82198 ≥98% (HPLC), powder
25mg
$ 299.00

Matrix Scientific
Benzofuran-2-carboxylicacid(4-morpholin-4-yl-butyl)-amide 95%+
1g
$ 702.00

DC Chemicals
CL-82198 >98%
100 mg
$ 250.00

DC Chemicals
CL-82198 >98%
1 g
$ 1000.00

DC Chemicals
CL-82198 >98%
250 mg
$ 500.00

Total 12 raw suppliers

Chemical Property of N-(4-morpholinobutyl)benzofuran-2-carboxamide

Chemical Property:

Vapor Pressure:7.06E-12mmHg at 25°C
Boiling Point:537.1°C at 760 mmHg
PKA:14.19±0.46(Predicted)
Flash Point:278.6°C
PSA：54.71000
Density:1.159±0.06 g/cm3(Predicted)
LogP:3.40580
Storage Temp.:Desiccate at RT
Solubility.:DMSO: >10mg/mL
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:302.16304257
Heavy Atom Count:22
Complexity:358

Purity/Quality:

97% ^*data from raw suppliers

CL 82198 hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CCCCNC(=O)C2=CC3=CC=CC=C3O2
Description CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 μg/ml. It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.

Technology Process of N-(4-morpholinobutyl)benzofuran-2-carboxamide

There total 1 articles about N-(4-morpholinobutyl)benzofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 6321-07-9
4-(4-aminobutyl)morpholine

: 3199-61-9
ethyl coumarilate

: 307002-71-7
CL-82198

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-3-ium; In toluene; at 150 ℃; for 10h; Glovebox; Inert atmosphere; Sealed tube;
DOI:10.1002/anie.201808560