4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester
• CAS No.: 1169563-99-8
• Molecular Formula: C₁₃H₂₂N₄O₂
• Molecular Weight: 266.343
• Hs Code.: 2933990090
• Mol file: 1169563-99-8.mol

Synonyms:4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester;4-(5-AMino-1H-pyrazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate

Chemical Property of 4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 465.1±45.0 °C(Predicted)
• PKA: 15.40±0.10(Predicted)
• PSA: 84.24000
• Density: 1.195±0.06 g/cm3(Predicted)
• LogP: 2.62550
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

4-(5-Amino-1H-pyrazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-(5-AMino-1H-pyrazol-3-yl)piperidin-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(2-cyanoacetyl)piperidine-1-carboxylic acid tert-butyl ester (660406-84-8) → tert-butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate (1169563-99-8,1269515-23-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 20h;

Reference yield: 83.0%

4-(2-cyanoacetyl)piperidine-1-carboxylic acid tert-butyl ester (660406-84-8) → 4-(5-amino-2H-pyrazol-3-yl)piperidine-1-carboxylic acid tert-butyl ester (1169563-99-8,1269515-23-2)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; at 80 ℃;

Reference yield:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) → 4-(5-amino-2H-pyrazol-3-yl)piperidine-1-carboxylic acid tert-butyl ester (1169563-99-8,1269515-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2: hydrazine hydrate / isopropyl alcohol / 80 °C

With potassium tert-butylate; hydrazine hydrate; In tetrahydrofuran; isopropyl alcohol;

upstream raw materials:

4-(2-cyanoacetyl)piperidine-1-carboxylic acid tert-butyl ester

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

Downstream raw materials:

tert-butyl 4-(3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-pyrazol-5-yl)piperidine-1-carboxylate

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