PD-137337

Base Information

Chemical Name:PD-137337
CAS No.:130406-71-2
Molecular Formula:C₃₅H₄₂N₄O₆
Molecular Weight:0
Hs Code.:

Synonyms:4-[(S)-2-[(S)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methylpropanoylamino]-1-phenylethylamino]-4-oxobutyric acid;CAM-1241;PD-137337

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of PD-137337

Chemical Property:

Purity/Quality:

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Technology Process of PD-137337

There total 10 articles about PD-137337 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 700-57-2
1-adamantanol

: 130406-71-2
*,R^*)>-4-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-phenylethyl>amino>-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 0.25 h

3: LiOH*H₂O / H₂O; dioxane / 18 h / Ambient temperature

4: 1.) 1-hydroxybenzotriazole hydrate, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2 h, 2.) 18 h

5: H₂ / Pearlman's catalyst / ethanol / 18 h / 25 °C / 2327.2 Torr

6: ethyl acetate / 24 h / Ambient temperature

With pyridine; lithium hydroxide; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00105a062

Reference yield:

: 130406-31-4
benzyl (S)-(2-hydroxy-1-phenylethyl)carbamate

: 130406-71-2
*,R^*)>-4-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-phenylethyl>amino>-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

2: NaN₃ / dimethylformamide / 3 h / 80 °C

3: Lindlar catalyst, H₂ / ethyl acetate / 6 h / 30 °C / 2327.2 Torr

4: 1.) 1-hydroxybenzotriazole hydrate, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2 h, 2.) 18 h

5: H₂ / Pearlman's catalyst / ethanol / 18 h / 25 °C / 2327.2 Torr

6: ethyl acetate / 24 h / Ambient temperature

With Lindlar's catalyst; sodium azide; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00105a062

Reference yield:

: 20989-17-7
(2S)-2-phenylglycinol

: 130406-71-2
*,R^*)>-4-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-phenylethyl>amino>-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / Et₃N / tetrahydrofuran / 18 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

3: NaN₃ / dimethylformamide / 3 h / 80 °C

4: Lindlar catalyst, H₂ / ethyl acetate / 6 h / 30 °C / 2327.2 Torr

5: 1.) 1-hydroxybenzotriazole hydrate, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2 h, 2.) 18 h

6: H₂ / Pearlman's catalyst / ethanol / 18 h / 25 °C / 2327.2 Torr

7: ethyl acetate / 24 h / Ambient temperature

With Lindlar's catalyst; sodium azide; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00105a062